Decellularization, Stabilization and Functionalization of Collagenous Tissues Used as Cardiovascular Biomaterials - Biomaterials: Physics and Chemistry - page 166

calcification (Jorge-Herrero et al., 2010). Several crosslinking techniques have been
suggested as the ideal procedure to stabilize the collagen structure while maintaining their
physical and natural shaping. The structure and name of some chemicals used as
crosslinking agents for collagenous tissue are shown in table 3.

Structure of stabilization agents Name Reference

Olde Damink et al., 1995;
Duncan & Boughner, 1998;
Langdon et al., 1999

Glutaraldehyde

Ethyl-aminopropyl
carbodiimide
(EDAC)

Lee et al., 1996; Everaerts et
al., 2004; Mendoza-Novelo
& Cauich-Rodríguez, 2009

e

hydroxysuccinimide
(NHS)

Glycerol diglycidyl ether Lee et al., 1994

Ethylene glycol
diglycidyl ether, n=1;
Poly(ethylene oxide)
diglycidyl ether, n=22

Tu et al., 1993; Sung et al.,
1996; Zeeman et al., 2000

Conolly et al., 2005; Sack et
al., 2007; Rapoport et al.,
2007

Triglycidylamine

Naimark et al., 1995; Olde
Damink et al., 1995;
Nowatzki & Tirrel, 2004

Hexamethylene
diisocyanate

Disuccinimidyl suberate Pathak et al., 2001

Sung et al. 1999; Sung et al.,
2000

Genipin

Proanthocyanidin,
Procyanidins

Han et al., 2003; Zhai et al.,
2009

Sung et al., 2002; Sung et al.,
2003

Reuterin