Biomedical Engineering Reference
In-Depth Information
haemocompatibility (in vivo and in vitro tests). Blank = native stainless steel stent,
native+chitosan.
d. QCM on model substrate slide: in situ monitoring of the LbL film growth on APTES-
coated silicon substrate.
Stainless steel screw
GA
Fibrinogen +
bisphosphonate
North et al., 2004
a. Sonication in acetone; acid etching; treatment in H 2 O 2 /NH 4 OH solution, 5 min at 80 °C.
b. Vapor deposition, 10 min at 60 °C; curing 1 h at 150°C; sonication in xylene.
c. Improvement of fixation of screws in rat tibia. Blank = test of bisphosphonate action.
d. Ellipsometry on model substrate slide: consistent increase of the film thickness
according to reaction steps.
Titanium
SMP
RGDC peptide
Xiao et al., 1997
a. Acid etching; rinsing with different solvents; outgassing.
b. In dry toluene, 120 °C, 3 h plus variants; sonication in various organic solvents and
water.
c. -
d. Ellipsometry and radiolabeling: growth of silane surface layer upon repeating
treatments. XPS peak shapes: semi-quantitatively consistent evolution according to
reaction steps.
Titanium GA Chitosan Martin et al., 2007
a. Polishing; cleaning in different solvents followed by nitric acid passivation or piranha
treatment.
b. In toluene, 24 h; sonication in toluene, ethanol and water.
c. -
d. XPS: elemental concentration, consistent evolution according to reaction steps.
Titanium none Heparin/fibronectin Li et al., 2011
a. Polishing; sonication in different solvents, drying 2 h at 60 °C ; NaOH treatment, 2h at
80°C.
b. In anhydrous ethanol, 10 h, sonication in ethanol; curing 6 h at 120 °C.
c. Improvement of blood compatibility and promotion of endothelialization. Blanks =
native, silanized.
d. XPS : survey spectra consistent with treatments. AFM: small clumps after APTES step,
and after APTES + protein step. Wet chemical analysis of proteins: consistent evolution
according to reaction steps.
Ti-6Al-4V
SMP
Cyclic peptides
Porté-Durrieu et al.,
2004
a. Substrate oxidation; outgassing at 150 °C.
b. In dry hexane under argon; rinsing with dry hexane; outgassing.
c. Increase of osteoprogenitor cells attachment. Blanks = native, native + peptide.
d. XPS: elemental concentration, consistent evolution according to reaction steps; N 1s
peak, demonstration of peptide retention; C 1s peak, majority of carbon of C-(C,H) type at
all stages.
Co-Cr-Mo; Ti-6Al-4V
GA
Trypsin
Puleo, 1997
a. Cleaning in different solvent, acid passivation.
b. In water 3 h or acetone 10 min; curing at 45 °C overnight.
c. Decrease of the loss of enzymatic activity as a function of time for Co-Cr-Mo, no effect
Search WWH ::




Custom Search