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[93] Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh CS, Culpepper JA, et al. Dendritic
cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J
Immunol 1995;154(10):5071-9.
[94] Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory func-
tions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev
Immunol 1995;13:251-76.
[95] Trinchieri G. Interleukin-12: a cytokine at the interface of inflammation and immunity.
Adv Immunol 1998;70:83-243.
[96] Kichian K, Nestel FP, Kim D, Ponka P, Lapp WS. IL-12 p40 message RNA expression in
target organs during acute graft-versus-host disease: possible involvement of IFN-
gamma. J Immunol 1996;157:2851-6.
[97] Sykes M, Szot GL, Nguyen PL, Pearson DA. Interleukin-12 inhibits murine graft-versus-
host disease. Blood 1995;86(6):2429-38.
[98] Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 regulates both Th1
and Th2 responses. Annu Rev Immunol 2001;19:423-74.
[99] Carroll HP, Paunovic V, Gadina M. Signalling, inflammation and arthritis. Crossed
signals: the role of interleukin-15 and -18 in autoimmunity. Rheumatology (Oxford)
2008;47(9):1269-77.
[100] Okamoto I, Kohno K, Tanimoto T, Iwaki K, Ishihara T, Akamatsu S, et al. IL-18 pre-
vents the development of chronic graft-versus-host disease in mice. J Immunol
2000;164(11):6067-74.
[101] Min CK, Maeda Y, Lowler K, Liu C, Clouthier S, Lofthus D, et al. Paradoxical effects of
interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and
CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood
2004;104(10):3393-9.
[102] Shaiegan M, Iravani M, Babaee GR, Ghavamzadeh A. Effect of IL-18 and sIL2R on
aGVHD occurrence after hematopoietic stem cell transplantation in some Iranian
patients. Transplant Immunol 2006;15(3):223-7.
[103] Fujimori Y, Takatsuka H, Takemoto Y, Hara H, Okamura H, Nakanishi K, et al. Elevated
interleukin (IL)-18 levels during acute graft-versus-host disease after allogeneic bone
marrow transplantation. Br J Haematol 2000;109(3):652-7.
[104] Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, et al. Lack of
IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Nature 1996;380(6575):630-3.
[105] Seder RA, Paul WE, Davis MM, Fazekas de St Groth B. The presence of interleukin 4 dur-
ing in vitro priming determines the lymphokine-producing potential of CD4+ T cells
from T cell receptor transgenic mice. J Exp Med 1992;176(4):1091-8.
[106] Hsieh CS, Heimberger AB, Gold JS, O'Garra A, Murphy KM. Differential regulation of T
helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-recep-
tor transgenic system. Proc Natl Acad Sci U S A 1992;89(13):6065-9.
[107] Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M. Th1 and Th2 mediate acute
graft-versus-host disease, each with distinct end-organ targets. J Clin Invest
2000;105(9):1289-98.
[108] Leveson-Gower DB, Olson JA, Sega EI, Luong RH, Baker J, Zeiser R, et al. Low doses of
natural killer T cells provide protection from acute graft-versus-host disease via an IL-
4-dependent mechanism. Blood 2011;117(11):3220-9.
[109] Pillai AB, George TI, Dutt S, Strober S. Host natural killer T cells induce an interleukin-
4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects
against graft-versus-host disease. Blood 2009;113(18):4458-67.
[110] Foley JE, Jung U, Miera A, Borenstein T, Mariotti J, Eckhaus M, et al. Ex vivo rapa-
mycin generates donor Th2 cells that potently inhibit graft-versus-host disease
and graft-versus-tumor effects via an IL-4-dependent mechanism. J Immunol
2005;175(9):5732-43.
[111] Nakamura K, Amakawa R, Takebayashi M, Son Y, Miyaji M, Tajima K, et al. IL-4-produc-
ing CD8(+) T cells may be an immunological hallmark of chronic GVHD. Bone Marrow
Transplant 2005;36(7):639-47.
[112] Vannier E, de Waal Malefyt R, Salazar-Montes A, de Vries JE, Dinarello CA. Interleu-
kin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis
in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein. Blood
1996;87(8):3307-15.
[113] Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the
IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat
Med 2006;12(1):99-106.
[114] Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, et al. Interleukin-13
induces tissue fibrosis by selectively stimulating and activating transforming growth
factor beta(1). J Exp Med 2001;194(6):809-21.
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