Natural killer cells in graftversus-host disease and graft-versus-leukemia - Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation - page 326

Table 15.1 Human and Mouse NK Cell Receptors and Ligands

Human Mouse

Receptor Ligand Receptor Ligand

Inhibitory receptors

KIR2DL1 HLA-C group 2 Ly49 A-C, E-G, I-O H-2 class I

KIR2DL2 HLA-C group 1 2B4 CD48

KIR2DL3 HLA-C group 1 CD94/NKG2A Qa-1b

KIR2DL4 HLA-G NKG2I Unknown

KIR2DL5 Unknown NKR-P1B, D Clr-b (Ocil)

KIR3DL1 HLA-A PILR- α , β CD99

KIR3DL2 HLA-A KLRG1 Cadherins

KIR3DL3 Unknown LAIR-1 Collagen

NKG2A HLA-E SICLEC-E Sialic acid

LIR-1 HLA class I

KLRGI Cadherins

Siglec7/9 Sialic acid

330

Activating receptors

KIR2DS1 HLA-C Ly49D H-2D d

KIR2DS2 Unknown Ly49P MCMV

KIR2DS3 Unknown Ly49H m157 MCMV

KIR2DS4 Unknown NKR-P1A Unknown

KIR2DS5 Unknown NKR-P1C (NK1.1) Unknown

KIR3DS1 Unknown NKR-P1F Clr-g

NKG2C HLA-E CD94/NKG2C, E Qa-1b

NKG2D MICA, MICB, ULBP1-4 NKG2D Rae-1s, H60, MULT-1

CD16 Ig CD16 IgG

NKp30 B7-H6, BAT3, CMV pp65 NKp46 Viral HA

NKp44 Viral HA DNAM-1 CD112, CD155

NKp46 Viral HA 2B4 CD48

NKp80 AICL CRACC CRACC

CD160 HLA-C LFA-1, CD11a ICAM-1, 2, 3

DNAM-1 CD112

CD96 CD155

2B4 CD48

CRACC CRACC

NTB-A NTB-A

LFA-1, CD11a ICAM-1, 2, 3

CD2 LFA-3

In the mouse, Ly49 receptors are type II membrane-anchored glycoproteins
that bind different MHC class I H-2 alleles. Although structurally different,
mouse Ly49s functionally resemble human KIRs in that both are involved in
the acquisition of tolerance to cells expressing self-MHC class I. The struc-
tural organization of Ly49s is divided into three regions, a ligand-binding