Biology Reference
In-Depth Information
[7] Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, et al. X-linked neona-
tal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equiva-
lent of mouse scurfy. Nat Genet 2001;27:18-20.
[8] Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The
immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is
caused by mutations of FOXP3. Nat Genet 2001;27:20-1.
[9] Fontenot JD, Dooley JL, Farr AG, Rudensky AY. Developmental regulation of Foxp3
expression during ontogeny. J Exp Med 2005;202:901-6.
[10] Hsieh CS, Lee HM, Lio CW. Selection of regulatory T cells in the thymus. Nat Rev Im-
munol 2012;12:157-67.
[11] Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of con-
served non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature
2010;463:808-12.
[12] Lohr J, Knoechel B, Kahn EC, Abbas AK. Role of B7 in T cell tolerance. J Immunol
2004;173:5028-35.
[13] Hinterberger M, Wirnsberger G, Klein L. B7/CD28 in central tolerance: costimulation
promotes maturation of regulatory T cell precursors and prevents their clonal deletion.
Front Immunol 2011;2:30.
[14] D'Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regu-
latory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005;6:1152-9.
[15] Lio CW, Hsieh CS. A two-step process for thymic regulatory T cell development. Im-
munity 2008;28:100-11.
[16] Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. IL-2 receptor beta-depen-
dent STAT5 activation is required for the development of Foxp3+ regulatory T cells.
J Immunol 2007;178:280-90.
[17] Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA, et al. Thy-
mic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
Nat Immunol 2001;2:301-6.
[18] Pacholczyk R, Kern J, Singh N, Iwashima M, Kraj P, Ignatowicz L. Nonself-antigens are
the cognate specificities of Foxp3+ regulatory T cells. Immunity 2007;27:493-504.
[19] Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L. Origin and T cell receptor diversity of
Foxp3+CD4+CD25+ T cells. Immunity 2006;25:249-59.
[20] Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR
repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol
2007;178:7032-41.
[21] Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. Recognition of the periph-
eral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004;21:267-77.
[22] Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, et al. T cell
receptor signal strength in Treg and iNKT cell development demonstrated by a novel
fluorescent reporter mouse. J Exp Med 2011;208:1279-89.
[23] Lee HM, Hsieh CS. Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset.
J Immunol 2009;183:2261-6.
[24] Klein L, Hinterberger M, Wirnsberger G, Kyewski B. Antigen presentation in the thymus
for positive selection and central tolerance induction. Nat Rev Immunol 2009;9:833-44.
[25] Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary
thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001;2:1032-9.
[26] Hauri-Hohl MM, Keller MP, Gill J, Hafen K, Pachlatko E, Boulay T, et al. Donor T-cell
alloreactivity against host thymic epithelium limits T-cell development after bone mar-
row transplantation. Blood 2007;109:4080-8.
[27] Krenger W, Blazar BR, Hollander GA. Thymic T-cell development in allogeneic stem cell
transplantation. Blood 2011;117:6768-76.
[28] Fisson S, Darrasse-Jeze G, Litvinova E, Septier F, Klatzmann D, Liblau R, et al. Continu-
ous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.
J Exp Med 2003;198:737-46.
[29] Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, et al. Immunologic
self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells:
induction of autoimmune disease by breaking their anergic/suppressive state. Int Im-
munol 1998;10:1969-80.
[30] Chen C, Rowell EA, Thomas RM, Hancock WW, Wells AD. Transcriptional regulation by
Foxp3 is associated with direct promoter occupancy and modulation of histone acety-
lation. J Biol Chem 2006;281:36828-34.
[31] Su L, Creusot RJ, Gallo EM, Chan SM, Utz PJ, Fathman CG, et al. Murine CD4+CD25+
regulatory T cells fail to undergo chromatin remodeling across the proximal promoter
region of the IL-2 gene. J Immunol 2004;173:4994-5001.
[32] Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural
Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of auto-
immune disease by IL-2 neutralization. J Exp Med 2005;201:723-35.
263
Search WWH ::




Custom Search