Biology Reference
In-Depth Information
Administration of cyclophosphamide after HCT not only prevents rejection,
but is also very effective for preventing acute and chronic GVHD because of
its effects on donor T cells that recognize recipient alloantigens. By sparing
donor T cells that do not recognize recipient alloantigens, this approach has
the additional advantage of jump-starting immune reconstitution, result-
ing in a reduced risk of opportunistic infection as compared to approaches
that deplete all T cells in the graft. A key unanswered question, however,
is whether this approach impairs immune effects that help to eliminate
malignant cells in the recipient. In theory, this problem could be addressed
by administration of donor lymphocytes later, after HCT, under conditions
where they have less propensity to cause GVHD.
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