Chemistry Reference
In-Depth Information
Table 9.4
% Erosion and
t
50
values of CMG and various
graft copolymer based tablets
for model drug ciprofloxacin
% Erosion
a
pH: 7.4
t
50
(min)
pH: 7.4
Polymer grade
CMG-g-PAM 1
58.2
351
CMG-g-PAM 2
64.5
309
CMG-g-PAM 3
57.0
483
CMG-g-PAM 4
52.8
514
CMG-g-PAM 5
48.3
567
CMG-g-PAM 6
42.7
716
CMG-g-PAM 7
50.3
542
CMG
81.6
248
M
t
M
α
W
i
W
d
ðtÞW
drug
1
a
100
where
W
i
is the initial dry weight of the tablet,
W
d
is the dry
weight of the tablet at time
t
, considering drug release at time
tðM
t
=M
α
Þ
Erosion
¼
%
W
i
,
M
t
is the amount of drug release at time
t
,
M
α
is the
total amount of drug released after infinite time, and
W
drug
is the
initial weight of drug (i.e., 5-ASA)
enclosed drug at the most sustained rate; hence, it is the most ideal matrix devel-
oped in this study, for controlled release of ciprofloxacin. Also the diffusion
exponent “
n
” remained between 0.5 and 1.0 (Table
9.4
). This explained that the
developed hydrogel-based matrix follows “non-Fickian” release behavior.
9.6 Summary
From the above theoretical and experimental observation, it is evident that by
grafting synthetic polymer on polysaccharide backbone, it is possible to develop
novel polymeric matrices, which are having wide application in the field of
biomedical science.
Acknowledgment
The authors are grateful to Indian School of Mines, Dhanbad, India, for
providing necessary facilities to carry out the reported drug delivery study. The authors also
earnestly acknowledge the financial support from University Grants Commissions, New Delhi,
India, in form of a research grant [No. 36-59/2008 (SR)].
References
1. Maity S, Ranjit S, Sa B (2010) Polysaccharide-based graft copolymers in controlled drug
delivery. Int J Pharm Tech Res 2:1350-1358
2. Kumar A, Singh K, Ahuja M (2009) Xanthan-g-poly (acrylamide): microwave-assisted
synthesis, characterization and in vitro release behaviour. Carbohydr Polym 76:261-267
3. Sinha VR, Kumria R (2001) Polysaccharides in colon-specific drug delivery. Int J Pharm
224:19-38
