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of an invagination, some additional tools have to be used for performing the separa-
tion of vesicles. In fact, in the first case, as we know, by general physical laws about
surface tension and minimal surface constraints, when the size of a vesicle grows
over a certain limit, automatically the separation happens. For invesiculation, some
cutting agents are required (and probably, other agents for closing the invagination
mouth need to be considered). In Fig. 4.7, a model of invagination driven by receptor
adherence is illustrated, which suggests the molecular basis of this phenomenon.
Fig. 4.6 Vesiculation: Devesiculation (top), Invesiculation (bottom)
Fig. 4.7 Receptor driven invagination
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