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References
1. Yang Y, Nunes FA, Berencsi K, Furth EE,
Gönczöl E, Wilson JM (1994) Cellular immu-
nity to viral antigens limits E1-deleted adeno-
viruses for gene therapy. Proc Natl Acad Sci
USA 91:4407-4411
2. Engelhardt JF, Litzky L, Wilson JM (1994)
Prolonged transgene expression in cotton rat
lung with recombinant adenoviruses defective
in E2a. Hum Gene Ther 5:1217-1229
3. Yang Y, Ertl HC, Wilson JM (1994) MHC
class I-restricted cytotoxic T lymphocytes to
viral antigens destroy hepatocytes in mice
infected with E1-deleted recombinant adeno-
viruses. Immunity 1:433-442
4. Schiedner G, Morral N, Parks RJ, Wu Y,
Koopmans SC, Langston C et al (1998)
Genomic DNA transfer with a high-capacity
adenovirus vector results in improved in vivo
gene expression and decreased toxicity. Nat
Genet 18:180-183
5. Ehrhardt A, Xu H, Dillow AM, Bellinger DA,
Nichols TC, Kay MA (2003) A gene-deleted
adenoviral vector results in phenotypic correc-
tion of canine hemophilia B without liver
toxicity or thrombocytopenia. Blood 102:
2403-2411
6. Brunetti-Pierri N, Palmer DJ, Mane V,
Finegold M, Beaudet al, Ng P (2005)
Increased hepatic transduction with reduced
systemic dissemination and proinfl ammatory
cytokines following hydrodynamic injection of
helper-dependent adenoviral vectors. Mol
Ther 12:99-106
7. Brunetti-Pierri N, Ng T, Iannitti DA, Palmer
DJ, Beaudet al, Finegold MJ et al (2006)
Improved hepatic transduction, reduced sys-
temic vector dissemination, and long-term
transgene expression by delivering helper-
dependent adenoviral vectors into the surgi-
cally isolated liver of nonhuman primates.
Hum Gene Ther 17:391-404
8. Brunetti-Pierri N, Liou A, Patel P, Palmer D,
Grove N, Finegold M et al (2012) Balloon
catheter delivery of helper-dependent adenovi-
ral vector results in sustained, therapeutic hFIX
expression in rhesus macaques. Mol Ther
20:1863-1870
9. Kreppel F, Kochanek S (2004) Long-term
transgene expression in proliferating cells
mediated by episomally maintained high-
capacity adenovirus vectors. J Virol 78:9-22
10. Schirmbeck R, Reimann J, Kochanek S,
Kreppel F (2008) The immunogenicity of ade-
novirus vectors limits the multispecifi city of
CD8 T-cell responses to vector-encoded trans-
genic antigens. Mol Ther 16:1609-1616
11. Kron MW, Engler T, Schmidt E, Schirmbeck
R, Kochanek S, Kreppel F (2011) High-
capacity adenoviral vectors circumvent the
limitations of
E3 adenovirus
vectors to induce multispecifi c transgene
product-directed CD8 T-cell responses.
J Gene Med 13:648-657
12. Kochanek S (1999) High-capacity adenoviral
vectors for gene transfer and somatic gene
therapy. Hum Gene Ther 10:2451-2459
13. Brunetti-Pierri N, Ng P (2011) Helper-
dependent adenoviral vectors for liver-directed
gene therapy. Hum Mol Genet 20:R7-R13
14. Segura MM, Alba R, Bosch A, Chillón M
(2008) Advances in helper-dependent adeno-
viral vector research. Curr Gene Ther
8:222-235
15. Parks RJ, Chen L, Anton M, Sankar U,
Rudnicki MA, Graham FL (1996) A helper-
dependent adenovirus vector system: removal
of helper virus by Cre-mediated excision of the
viral packaging signal. Proc Natl Acad Sci USA
93:13565-13570
16. Ng P, Beauchamp C, Evelegh C, Parks R,
Graham FL (2001) Development of a FLP/frt
system for generating helper-dependent ade-
noviral vectors. Mol Ther 3:809-815
17. Umaña P, Gerdes CA, Stone D, Davis JR,
Ward D, Castro MG et al (2001) Effi cient
FLPe recombinase enables scalable production
of helper-dependent adenoviral vectors with
negligible helper-virus contamination. Nat
Biotechnol 19:582-585
18. Dormond E, Meneses-Acosta A, Jacob D,
Durocher Y, Gilbert R, Perrier M et al (2009)
An effi cient and scalable process for helper-
dependent adenoviral vector production using
polyethylenimine-adenofection.
Δ
E1 and
Δ
E1/
Δ
Biotechnol
Bioeng 102:800-810
19. Alba R, Hearing P, Bosch A, Chillon M (2007)
Differential amplifi cation of adenovirus vectors
by fl anking the packaging signal with attB/
attP-PhiC31 sequences: implications for
helper-dependent adenovirus production.
Virology 367:51-58
20. Palmer D, Ng P (2003) Improved system for
helper-dependent adenoviral vector produc-
tion. Mol Ther 8:846-852
21. Parks RJ, Bramson JL, Wan Y, Addison CL,
Graham FL (1999) Effects of stuffer DNA on
transgene expression from helper-dependent
adenovirus vectors. J Virol 73:8027-8034
