Biology Reference
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Fig. 2
Immune sensing hypothesis of cytomegalovirus latency control illustrated for pulmonary
latency in the BALB/c (
H-2
d
haplotype) mouse model.
a
Viral gene transcription and immune
sensing during latency of wild type mCMV. Most viral genomes, symbolized as episomes associ-
ated with cellular histones in a closed higher-order chromatin-like structure, are in a state of MIE
locus silencing. Stochastic episodes of open viral chromatin structure at the MIE locus result in
IE1 transcription, IE1 protein processing, and MHC class I L
d
-restricted presentation of the IE1
peptide 168-YPHFMPTNL-176 to IE1 epitope-specific effector-memory CD8 T cells (IE1-T
EM
),