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Fig. 2 Immune sensing hypothesis of cytomegalovirus latency control illustrated for pulmonary
latency in the BALB/c ( H-2 d haplotype) mouse model. a Viral gene transcription and immune
sensing during latency of wild type mCMV. Most viral genomes, symbolized as episomes associ-
ated with cellular histones in a closed higher-order chromatin-like structure, are in a state of MIE
locus silencing. Stochastic episodes of open viral chromatin structure at the MIE locus result in
IE1 transcription, IE1 protein processing, and MHC class I L d -restricted presentation of the IE1
peptide 168-YPHFMPTNL-176 to IE1 epitope-specific effector-memory CD8 T cells (IE1-T EM ),
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