Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression - Human Cytomegalovirus - page 99

Gibson 1983), but the significance of this or other posttranslational modifications
to these proteins remains largely unexplored.

Table 1 Human cytomegalovirus tegument proteins with known or predicted functions
Gene, protein Phenotype Function(s) References

UL26 A Increases stability Munger et al. 2006

of virion proteins Lorz et al. 2006

UL32 - pp150 E Directs capsid to site AuCoin et al. 2006

of final envelopment

UL35 A Activates viral gene expression Schering et al. 2005

UL36 D Inhibits apoptosis Skaletskaya et al. 2001

UL38 A Inhibits apoptosis Terhune et al. 2007

UL45 A Inactive (?) ribonucleotide Patrone et al. 2003

reductase subunit

UL47 A Release of viral DNA Bechtel and Shenk 2002

from capsid

UL48 E Deubiquitinating protease Wang et al. 2006

Release of viral DNA from capsid Bechtel and Shenk 2002

UL69 A Nuclear export of unspliced mRNAs Lischka et al. 2006

Arrests cell cycle in G1 Lu and Shenk 1999

UL77 E Putative pyruvoyl decarboxylase Yoakum 1993

UL82 - pp71 A Degrades Daxx, facilitates Saffert and Kalejta 2006

IE gene expression

Degrades Rb, stimulates cell Kalejta et al. 2003

cycle progression

Prevents cell surface Trgovcich et al. 2006

expression of MHC

UL83 - pp65 D Endogenous kinase activity Yao et al. 2001

Associated kinase activity Gallina et al. 1999

Evasion of adaptive immunity Gilbert et al. 1996

Evasion of innate immunity Arnon et al. 2005

UL94 A/E Putative DNA-binding protein Wing et al. 1996

Similar to autoantigen Lunardi et al. 2000

in systemic sclerosis

UL97 A Kinase that phosphorylates Littler et al. 1992

ganciclovir Sullivan et al. 1992

Stimulates DNA replication, M. Prichard et al. 1999

assembly/egress

UL99 - pp28 E Directs enclosure Silva et al. 2003

of enveloped particles
IRS1/ TRS1 A/E Inhibits PKR antiviral response Hakki et al. 2006
Virion assembly Adamo et al. 2003
US24 A Activates viral gene expression Feng et al. 2006
Genes that encode tegument proteins along with commonly accepted protein names (if applicable)
are shown in column 1. Phenotype (column 2), listed as augmenting (A), dispensable (D) or essential
(E), refers to the requirement of the gene for lytic replication in human fibroblast cells in vitro as
determined in either the provided reference (column 4), the two global mutational analyses of human
cytomegalovirus (Dunn et al. 2003; Yu et al. 2003) or as described in a recent review (Mocarski et al.
2007). Column 3 displays either demonstrated or inferred functions for these proteins