Biomedical Engineering Reference
In-Depth Information
(3) Dimensional analysis scale-up
The so-called dimensional analysis scale-up method maintains the dimensionless
group (also known as dimensionless number) of bioreactor system parameters
constant. There are strict restrictions for the application law, but this method is
useful. If the momentum of the reaction system, quality, heat balance, and relevant
boundary conditions, initial conditions in dimensionless form for the amplification
process are listed, it is a dimensional analysis scale-up method.
For the dimensional analysis scale-up method, reasonable construction of the
quasi-number is the key, and determination of the relevant parameters is the first
step. During bioreactor enlargement under specific circumstances, it is necessary to
analyze the system mode and identify the key control mechanism of the reaction
system and then to amplify them and do not use this method mechanically.
(4) Experience scale-up
Currently, the experience scale-up is the most widely used method, such as the scale-
up principle according to constant
K
La
,
P
/
V
,Re,
N
,
or
v
tip
. Generally, to ensure that
the individual criterion are equal at scale-up, whether the change of other criteria
lead to changes of the flow pattern or damage to the microorganisms must be taken
into account and changes made accordingly.
11.4.2.2
Research Methods for Scale-Down
To more accurately simulate the unevenness that exists in a large-reactor environ-
ment, the narrowed bioreactor has played a more important role than bioreactor
magnification. The construction of scaled-down equipment is a beneficial sup-
plement for the mathematical model, scale-up norms, and traditional pilot plant
operation. Based on the scale-down of biological reactors, researchers find that
small-scale biological reaction system could measure more parameters faster and
also assess the effect of changes according to the present operation process [
159
].
For the narrowed bioreactor research methods, compared to bioreactor magnifi-
cation research methods, the narrowing of the reactor can also based on the constant
input volume power and
K
La
.
11.4.3
Integration Research Methods for
the Biotransformation Process and Engineering
of Lignocellulose
The integration of the biotransformation process and engineering of lignocellulose
focuses on the important factors in the system, including material integration, energy
integration, information integration, and water system integration.
