Aerospace Toxicology Overview: Aerial Application and Cabin Air Quality - Reviews of Environmental Contamination and Toxicology - page 21

Table 1 A summary of aerial application-related studies conducted at the Civil Aerospace Medical
Institute
Agent(s) or topic Summary Reference

Lindane and dieldrin Alterations in several biochemical values of rat

tissues by chronic exposures to lindane and
changes in the uptake of L-methionine by
chick heart and liver cells by chronic
exposure to dieldrin

Daugherty et al.
( 1962 )

Analysis of hazards
in the aerial
application

Discussion on the nature of the chemicals,
the symptoms of toxicity, recommended
treatment, and suggestions for safe
handling of toxic pest-control chemicals

Smith ( 1962 )

Cardiovascular effects
of endrin

Causation of bradycardia, hypertension,
salivation, hyperexcitability, tonic-clonic
convulsions, increased body temperature,
leukocytosis, and decreased blood pH by
endrin, appeared to be caused by direct
action on the central nervous system

Emerson et al.
( 1963 )

Dieldrin, lindane, hep-
tachlor, isodrin, and
endrin

Reduction in the esteriication of inorganic
phosphate by 50%, without affecting lactic
acid production in chickens and rats exposed
to dieldrin, but no such reduction in
esteriication by other chlorinated pesticides
lindane, heptachlor, isodrin, and endrin

Daugherty et al.
( 1963 )

Cases involving
aerial application
of organophosphorus
insecticides

Signs/symptoms of anxiety, uneasiness, depres-
sion, weeping, dizziness, emotional liability,
disagreement with family/coworkers, and
unable to perform familiar tasks

Dille and Smith
( 1963 )

Chronic and acute
effects of endrin
on renal function

Systemic hypertension and increased renal
vascular resistance in dogs by acute exposure
to endrin, attributed to a sympathoadrenal
action

Reins et al.
( 1963 )

Development of progressive systemic
hypotension with variable changes in renal
function and terminal renal vasodilatation in
dogs chronically exposed to endrin
Note: These indings were related to hemody-
namic alterations in the peripheral vasculature.
No evidence of renal failure was observed due
to chronic insecticide poisoning.

Effects of endrin
and carbon tetrachloride

Reversible increase in hepatic fat contents of rats
treated with endrin and carbon tetrachloride

Clark ( 1966a )

Pathological effects of
endrin and dieldrin

More severe effects of dieldrin on the cold-
adapted rats than on the room-temperature
rats

Clark ( 1966b )

Hinshaw et al.
( 1966 )

Effects of endrin on renal
function and hemody-
namics, peripheral
vascular system, venous
return and catecholamine
release, and the
cardiovascular system

Exploration of the effects of endrin in dogs on
renal function and hemodynamics, peripheral
vascular system, venous return and cat-
echolamine release, and the cardiovascular
system; and elucidation of the mechanisms of
endrin-induced hemoconcentration

(continued)