Biology Reference
In-Depth Information
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MIAPE guidelines
. They describe the minimum information
needed to appropriately report information and data about a
proteomics experiment. Objectives and principles of MIAPE
guidelines are defi ned in a parent document [
4
], which
describes the minimum information that describes the experi-
mental context, allows the understanding of the results and
their interpretation suffi ciently to permit a critical evaluation
and, in principle, a potential recreation of the work. However,
it is important to stress the fact that MIAPE guidelines intend
neither to make any data quality judgement, nor to fi x any
data format for its representation or to try to establish the way
to run an experiment. MIAPE guidelines have been defi ned in
a modular way, and each MIAPE module defi nes the mini-
mum information related to a certain part of the proteomics
data fl ow. HUPO-PSI has currently produced nine different
MIAPE documents/modules that will be described later in
this chapter.
Data Formats, Controlled Vocabularies and MIAPEs are
strongly interrelated since Controlled Vocabularies provide the
way to represent proteomics data in the standard data fi les, and
MIAPE modules defi ne which data the fi le should contain to be
MIAPE-compliant (Table
1
).
Standards produced by HUPO-PSI are reported to the scien-
tifi c community following a set of formal requirements defi ned by
the initiative itself. Accordingly, documents can be one of the
following types:
(a)
Community practice documents
, which inform and infl uence
the community regarding an approach or process that is con-
sidered to be widely accepted by consensus and practice in the
Proteomics community.
(b)
Informational documents
, which inform the community of an
interesting and useful proteomics-related technology, architec-
ture, framework or concept
(c)
MIAPE (minimum information about a proteomics experi-
ment) documents
, which inform the community as to the
minimal information that should be captured about an
experiment to enable its results to be clearly interpreted and
validated.
(d)
Recommendation documents
, which describe a particular tech-
nical specifi cation or a particular set of guidelines for the appli-
cation of a technical specifi cation. Recommendations are
intended to guide interoperability and promote standard
approaches.
