Biology Reference
In-Depth Information
vivo gene knockdown mediated by virally delivered miRNAs is a
relatively inexpensive and very fl exible technique allowing for rapid
elucidation of the gene's functional role in a variety of neurobio-
logical processes.
References
1. Fire A, Xu S, Montgomery MK et al (1998)
Potent and specifi c genetic interference by
double-stranded RNA in Caenorhabditis ele-
gans. Nature 19:806-811
2. Lewis BP, Burge CB, Bartel DP (2005)
Conserved seed pairing, often fl anked by aden-
osines, indicates that thousands of human
genes are microRNA targets. Cell 120:15-20
3. Mello CC, Conte D (2004) Revealing the
world of RNA interfer. Nature 431:338-342
4. Bernstein E, Caudy AA, Hammond SM et al
(2001) Role for a bidentate ribonuclease in the
initiation step of RNA interference. Nature
409:363-366
5. Zamore PD, Tuschl T, Sharp PA et al (2000)
RNAi: double-stranded RNA directs the ATP-
dependent cleavage of mRNA at 21 to 23
nucleotide intervals. Cell 101:25-33
6. Hammond SM, Bernstein E, Beach D et al
(2000) An RNA-directed nuclease mediates
post-transcriptional
14. Zeng Y, Wagner EJ, Cullen BR (2002) Both
natural and designed micro RNAs can inhibit the
expression of cognate mRNAs when expressed
in human cells. Mol Cell 9:1327-1333
15. Yekta S, Shih I-H, Bartel DP (2004)
MicroRNA-directed cleavage of HOXB8
mRNA. Science 304:594-596
16. Petersen CP, Bordeleau M-E, Pelletier J et al
(2006) Short RNAs repress translation after
initiation in mammalian cells. Mol Cell 21:
533-542
17. Bartel DP (2009) MicroRNAs: target recogni-
tion and regulatory functions. Cell 136:215-233
18. Lagos-Quintana M, Rauhut R, Yalcin A et al
(2002) Identifi cation of tissue-specifi c microR-
NAs from mouse. Curr Biol 12:735-739
19. Aravin AA, Lagos-Quintana M, Yalcin A et al
(2003) The small RNA profi le during
Drosophila melanogaster
development. Dev
Cell 5:337-350
20. Brennecke J, Hipfner DR, Stark A et al (2003)
bantam encodes a developmentally regulated
microRNA that controls cell proliferation and
regulates the proapoptotic gene hid in
Drosophila. Cell 113:25-36
21. Lee Y, Jeon K, Lee J-T et al (2002) MicroRNA
maturation: stepwise processing and subcellu-
lar localization. EMBO J 17:4663-4670
22. Lee Y, Ahn C, Han J et al (2003) The nuclear
RNase III Drosha initiates microRNA process-
ing. Nature 425:415-419
23. Yi R, Qin Y, Macara IG et al (2003) Exportin-5
mediates the nuclear export of pre-microRNAs
and short hairpin RNAs. Genes Dev
17:3011-3016
24. Lund E, Güttinger S, Calado A et al (2004)
Nuclear export of microRNA precursors.
Science 303:95-98
25. Hutvágner G, McLachlan J, Pasquinelli AE
et al (2001) A cellular function for the RNA-
interference enzyme Dicer in the maturation
of the let-7 small temporal RNA. Science
293:834-838
26. Nykänen A, Haley B, Zamore PD (2001) ATP
requirements and small interfering RNA struc-
ture in the RNA interference pathway. Cell
107:309-321
27. Martinez J, Patkaniowska A, Urlaub H et al
(2002) Single-stranded antisense siRNAs
guide target RNA cleavage in RNAi. Cell
110:563-574
gene
silencing
in
Drosophila cells. Nature 404:293-296
7. Manche L, Green SR, Schmedt C et al (1992)
Interactions between double-stranded RNA
regulators and the protein kinase DAI. Mol
Cell Biol 12:5238-5248
8. Hunter T, Hunt T, Jackson RJ et al (1975)
The characteristics of inhibition of protein syn-
thesis by double-stranded ribonucleic acid in
reticulocyte
lysates.
J
Biol
Chem
250:409-417
9. Minks MA, West DK, Benvin S et al (1979)
Structural requirements of double-stranded
RNA for the activation of 2
′
,5
′
-oligo(A) poly-
merase and protein kinase of interferon-treated
HeLa cells. J Biol Chem 254:10180-10183
10. Elbashir SM, Harborth J, Lendeckel W et al
(2001) Duplexes of 21-nucleotide RNAs
mediate RNA interference in cultured mam-
malian cells. Nature 411:494-498
11. Doench JG, Petersen CP, Sharp PA (2003)
siRNAs can function as miRNAs. Genes Dev
17:438-442
12. Pillai RS, Bhattacharyya SN, Artus CG et al
(2005) Molecular biology: inhibition of trans-
lational initiation by let-7 microRNA in human
cells. Science 309:1473-1576
13. Meister G, Landthaler M, Patkaniowska A et al
(2004) Human Argonaute2 mediates RNA
cleavage targeted by miRNAs and siRNAs.
Mol Cell 15:185-197
Search WWH ::
Custom Search