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Fig. 4 In Vivo Expression of CREBCA Enhances NMDAR-mediated but not
AMPAR-mediated Synaptic Transmission. ( a ) Dual whole-cell patch clamp
recordings of infected and neighbor uninfected neurons allow for measure-
ments and comparison of AMPAR and NMDAR amplitudes. In this confi guration,
the stimulus position and intensity are identical between the two cells, which
permit the most accurate comparison of cell properties between the molecularly
manipulated and the naïve neuron. ( b ) Average percent change of AMPAR EPSCs
of CREBCA-expressing neurons relative to neighboring uninfected control neu-
rons ( n =20). Overlay of sample EPSCs of a pair is shown (Scale bars:
20 ms/20 pA). ( c ) Average percent change of NMDAR EPSCs of CREBCA-
expressing neurons relative to neighboring uninfected control neurons ( n = 19).
Overlay of sample EPSCs of a pair is shown (Scale bars: 20 ms/20 pA). *P< 0.05.
(Adapted from [ 14 ] )
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