Biology Reference
In-Depth Information
in the brain impairs memory. Nature 440:
352-357
131. Roselli F, Tirard M, Lu J, Hutzler P, Lamberti
P, Livrea P, Morabito M, Almeida OF (2005)
Soluble beta-amyloid1-40 induces NMDA-
dependent degradation of postsynaptic den-
sity-95 at glutamatergic synapses. J Neurosci
25:11061-11070
132. Shankar GM, Li S, Mehta TH, Garcia-Munoz
A, Shepardson NE, Smith I, Brett FM, Farrell
MA, Rowan MJ, Lemere CA, Regan CM,
Walsh DM, Sabatini BL, Selkoe DJ (2008)
Amyloid-beta protein dimers isolated directly
from Alzheimer's brains impair synaptic plas-
ticity and memory. Nat Med 14:837-842
133. Bowers WJ, Mastrangelo MA, Stanley HA,
Casey AE, Milo LJ Jr, Federoff HJ (2005)
HSV amplicon-mediated Abeta vaccination in
Tg2576 mice: differential antigen-specifi c
immune responses. Neurobiol Aging 26:
393-407
134. Frazer ME, Hughes JE, Mastrangelo MA,
Tibbens JL, Federoff HJ, Bowers WJ (2008)
Reduced pathology and improved behavioral
performance in Alzheimer's disease mice vac-
cinated with HSV amplicons expressing
amyloid-beta and interleukin-4. Mol Ther
16:845-853
135. Peruzzi PP, Lawler SE, Senior SL, Dmitrieva
N, Edser PA, Gianni D, Chiocca EA, Wade-
Martins R (2009) Physiological transgene
regulation and functional complementation
of a neurological disease gene defi ciency in
neurons. Mol Ther 17:1517-1526
136. Cousins SL, Hoey SE, Anne Stephenson F,
Perkinton MS (2009) Amyloid precursor pro-
tein 695 associates with assembled NR2A-
and NR2B-containing NMDA receptors to
result in the enhancement of their cell surface
delivery. J Neurochem 111:1501-1513
137. Hoey SE, Williams RJ, Perkinton MS (2009)
Synaptic NMDA receptor activation stimu-
lates alpha-secretase amyloid precursor pro-
tein processing and inhibits amyloid-beta
production. J Neurosci 29:4442-4460
138. Paoletti P (2011) Molecular basis of NMDA
receptor functional diversity. Eur J Neurosci
33:1351-1365
139. Decker H, Jurgensen S, Adrover MF, Brito-
Moreira J, Bomfi m TR, Klein WL, Epstein
AL, De Felice FG, Jerusalinsky D, Ferreira
ST (2010) N-methyl-D-aspartate receptors
are required for synaptic targeting of
Alzheimer's toxic amyloid-beta peptide
oligomers. J Neurochem 115:1520-1529
140. Adrover MF, Guyot-Revol V, Cheli VT,
Blanco C, Vidal R, Alche L, Kornisiuk E,
Epstein
Hippocampal infection with HSV-1-derived
vectors expressing an NMDAR1 antisense
modifi es behavior. Genes Brain Behav 2:
103-113
141. Liu J, Chang L, Roselli F, Almeida OF, Gao
X, Wang X, Yew DT, Wu Y (2010) Amyloid-
beta induces caspase-dependent loss of PSD-
95 and synaptophysin through NMDA
receptors. J Alzheimers Dis 22:541-556
142. Balducci C, Beeg M, Stravalaci M, Bastone A,
Sclip A, Biasini E, Tapella L, Colombo L,
Manzoni C, Borsello T, Chiesa R, Gobbi M,
Salmona M, Forloni G (2010) Synthetic
amyloid-beta oligomers impair long-term mem-
ory independently of cellular prion protein.
Proc Natl Acad Sci USA 107:2295-2300
143. During MJ, Naegele JR, O'Malley KL, Geller
AI (1994) Long-term behavioral recovery in
parkinsonian rats by an HSV vector express-
ing tyrosine hydroxylase. Science 266:
1399-1403
144. Sun M, Zhang GR, Kong L, Holmes C, Wang
X, Zhang W, Goldstein DS, Geller AI (2003)
Correction of a rat model of Parkinson's dis-
ease by coexpression of tyrosine hydroxylase
and aromatic amino acid decarboxylase from a
helper virus-free herpes simplex virus type 1
vector. Hum Gene Ther 14:415-424
145. Sun M, Kong L, Wang X, Holmes C, Gao Q,
Zhang GR, Pfeilschifter J, Goldstein DS, Geller
AI (2004) Coexpression of tyrosine hydroxy-
lase, GTP cyclohydrolase I, aromatic amino
acid decarboxylase, and vesicular monoamine
transporter 2 from a helper virus-free herpes
simplex virus type 1 vector supports high-
level, long-term biochemical and behavioral
correction of a rat model of Parkinson's dis-
ease. Hum Gene Ther 15:1177-1196
146. Zhang GR, Wang X, Yang T, Sun M, Zhang
W, Wang Y, Geller AI (2000) A tyrosine
hydroxylase-neurofi lament chimeric pro-
moter enhances long-term expression in rat
forebrain neurons from helper virus-free
HSV-1 vectors. Brain Res Mol Brain Res
84:17-31
147. Gao Q, Sun M, Wang X, Geller AI (2007)
Isolation of an enhancer from the rat tyrosine
hydroxylase promoter that supports long-
term, neuronal-specifi c expression from a
neurofi lament promoter, in a helper virus-free
HSV-1 vector system. Brain Res 1130:1-16
148. Zhang GR, Li X, Cao H, Zhao H, Geller AI
(2011) The vesicular glutamate transporter-1
upstream promoter and fi rst intron each sup-
port glutamatergic-specifi c expression in rat
postrhinal cortex. Brain Res 1377:1-12
149. Zhang GR, Geller AI (2010) A helper virus-
free HSV-1 vector containing the vesicular
AL,
Jerusalinsky
D
(2003)
Search WWH ::




Custom Search