Chemistry Reference
In-Depth Information
CHAPTER 10
Nonlamellar Lipid Liquid Crystalline
Structures at Interfaces
DEBBY P. CHANG and TOMMY NYLANDER
Physical Chemistry, Lund University, Lund, Sweden
Abstract
Nonlamellar lipid-based liquid crystalline structures, such as cubic, hexagonal, and
sponge phases, have potential as delivery systems in pharmaceutical, food, and cosmetic
applications. This is due to the space-dividing nature of these phases, which features
mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To
utilize these nonlamellar liquid crystalline structures as delivery vehicles, it is crucial
to understand how they interact with and respond to different types of interfaces. The
progress in the area of liquid crystalline lipid-based nanoparticles opens up new pos-
sibilities for preparation of well-defi ned surface fi lms with well-defi ned nanostructure.
Apart from the relevance to drug delivery, such studies create opportunities for new
applications for functionalized and tunable surface coatings as well. This review will
focus on recent progress in the formation of nonlamellar dispersion and its interfacial
properties at the solid-liquid and biologically relevant interfaces. Various experimental
techniques on the study of interfacial interactions of these crystalline structures will be
discussed.
10.1
Introduction
290
10.2
Background
291
10.2.1
Lipid Phases
291
10.2.2
Formation of Nonlamellar Crystalline Particles
294
10.3
Characterization Techniques
295
10.3.1
Neutron Refl ectometry
296
10.3.2
Null Ellipsometry
297
10.3.3
Quartz Crystal Microbalance with Dissipation
297
10.3.4
Attenuated Total Refl ectance and Fourier Transform Infrared
297
10.3.5
Fluorescence and Confocal Microscopy
298
Search WWH ::
Custom Search