Stimuli-Responsive Lipid -Based Self-Assembled Systems - Self-Assembled Supramolecular Architectures: Lyotropic Liquid Crystals - page 273

It is notable that no drug delivery products have yet made it to market
based on stimuli-responsive systems. A heat-sensitive liposome system con-
taining doxorubicin for heat-selective tumor delivery (Thermodox owned by
Celsion) has entered clinical trials. However, the potential for accidental
activation of the delivery system needs to be carefully controlled to avoid
inadvertent activation in nontarget tissues, consequently it might be expected
that alternative means of activation such as optical, will ultimately be viewed
as a safer approach to on-demand delivery systems. The major hurdle to prog-
ress in light-activated delivery systems is the need to include light-responsive
elements that may themselves be prohibitively toxic and require their own
highly costly preclinical and clinical toxicological evaluation. Hence the search
continues for the ideal selective responsive drug delivery system that meets
the demands of functionality, safety, and toxicity.
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