Chemistry Reference
In-Depth Information
CHAPTER 9
Stimuli-Responsive Lipid-Based
Self-Assembled Systems
BEN J. BOYD and WYE-KHAY FONG
Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences,
Monash Universtiy, Parkville, Victoria, Australia
Abstract
Lipid based self assembled matrices have been proposed as novel drug delivery systems,
as the phases formed by these materials have been shown to reliably encapsulate and
control the release of actives. The unique nanostructures formed by many lipids are
dictated by the specifi c local packing of the amphiphiles in the matrix. Lipid packing
is determined by molecular geometry of the lipids, which can be reversibly or irrevers-
ibly modifi ed by changes in environmental factors such as temperature and pH. In
recent times, much research has tapped into the rich vein of liquid crystalline nano-
structures and their manipulations for “on-demand” drug release. This chapter details
the use of self assembled systems in drug delivery with a particular focus on how they
have been rendered stimuli responsive and their potential uses in pharmaceutical
therapies.
9.1
Lipid Self - Assembly and Transitions between Self - Assembled Structures
258
9.1.1
Lipid Self - Assembly
258
9.1.2
Transitions between Self - Assembled Structures
259
9.2
Application of Self - Assembled Systems in Drug Delivery and the
Case for Stimuli - Responsive Systems
260
9.2.1
Benefi ts of Self-Assembled Systems in Drug Delivery
260
9.3
Stimuli - Responsive Systems
261
9.3.1
Endogenous Stimuli
262
9.3.2
External Stimuli
267
9.4
Future Directions of Stimuli - Responsive Systems
276
References
277
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