Recent Developments in Lyotropic Liquid Crystals as Drug Delivery Vehicles - Self-Assembled Supramolecular Architectures: Lyotropic Liquid Crystals - page 228

(a)

(b)

a =~57Å

(d)

(c)

a =~60Å

a =~51Å

(f)

(e)

a =~53Å

a =~58Å

Figure 8.9 (a) Schematic illustration of the H II mesophase general structure. The
water populates the inner region of the cylinders; the GMO tails as well as the TAG
point outward. (b) Single “blank,” empty system of the H II mesophase and (c) Na-DFC-
loaded system. The drug populates the interfacial area and causes channel shrinkage.
(d) NONA - loaded H II mesophase. The peptide populates the aqueous channels and
swells them. (e, f) PEN-loaded systems. At low PEN concentration (e), it is adsorbed
on the GMO head groups and causes channel shrinkage. With increasing PEN concen-
tration (f), it populates an additional hosting region at the interface (Cohen-Avrahami
et al., 2011 ).

this analysis provides information on the rate-determining step in the CPP
enhancement.
The emptying experiments revealed a surprising result. The control system,
without CPP, released the largest quantities of Na-DFC with time. The release
from the PEN systems was the second in order, whereas NONA and RALA
systems released the lowest quantities of Na-DFC (Fig. 8.11a).