Self-Assembly in Lipidic Particles - Self-Assembled Supramolecular Architectures: Lyotropic Liquid Crystals - page 150

well preserved during the dispersion procedure: It was identical to the cor-
responding system of the fully hydrated nondispersed phase. As a conse-
quence, it displayed an interesting temperature-dependent behavior (the
breathing mode ) during heating-cooling cycles, that is, it demonstrated a
reversible water deswelling-swelling behavior during heating-cooling cycles.
3 . Control of the Internal Nanostructure. Our results revealed that the
internal nanostructure of the kinetically stabilized aqueous dispersions based
on MLO-water binary and ternary MLO-TC-water mixtures could be modu-
lated by varying the lipid composition: The replacement of MLO by binary
MLO-DGMO mixtures signifi cantly affected the internal nanostructures.
4 . Concentrated Nanostructured Dispersions with a Controllable Droplet
Size . In a recent report (Salentinig et al., 2008), concentrated ISAsomes with
various internal structures were also prepared with a laboratory-built shear
device. This is achieved within a very short time interval (a few seconds) by
using a similar approach to that proposed by Bibette's method (Mason and
Bibette, 1996, 1997), which is well-known for the preparation of monodis-
persed emulsions. The interested reader can fi nd more details on this technique
in the contribution of Glatter and Kulkarni in this topic.
5 . Potential Applications . The formation and characterization of ISA-
somes and the functionalization of their confi ned nanostructures is an impor-
tant topic in nanotechnology. These dispersions can be utilized in various
applications in food and pharmaceutical industries (Boyd, 2005; Drummond
and Fong, 2000; Larsson, 2009; Leser et al., 2006; Malmsten, 2006; Mezzenga
et al., 2005; Siekmann et al., 2002; Yaghmur and Glatter, 2009). They are par-
ticularly interesting for the formulation of nanoparticulate delivery systems of
drugs and bioactive materials. It is also interesting to check the potential
applications of the concentrated nanostructured aqueous dispersions as reser-
voirs for enhanced solubilization of bioactive ingredients including proteins
and peptides and for the generation of active molecules.

REFERENCES

Almsherqi , Z. A. , Kohlwein , S. D. , and Deng , Y. ( 2006 ). Cubic membranes: A legend
beyond the Flatland of cell membrane organization. Journal of Cell Biology , 173 ,
839 - 844 .
Angelova , A. , Angelov , B. , Papahadjopoulos - Sternberg , B. , Bourgaux , C. , and Couvreur ,
P. ( 2005 ). Protein driven patterning of self - assembled cubosomic nanostructures:
Long oriented nanoridges. Journal of Physical Chemistry B , 109 , 3089 - 3093 .
Angelov , B. , Angelova , A. , Garamus , V. M. , Lebas , G. , Lesieur , S. , Ollivon , M. , Funari ,
S. S. , Willumeit , R. , and Couvreur , P. ( 2007 ). Small - angle neutron and x - ray scattering
from

amphiphilic stimuli - responsive diamond - type bicontinuous cubic phase .

Journal of the American Chemical Society , 129 , 13474 - 13479 .
Barauskas , J. , and Landh , T. ( 2003 ). Phase behavior of the phytantriol/water system .
Langmuir , 19 , 9562 - 9565 .