Chemistry Reference
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CHAPTER 5
Self-Assembly in Lipidic Particles
ANAN YAGHMUR
Department of Chemistry, University of Graz, Graz, Austria
Department of Pharmacy, School of Pharmaceutical Sciences, Faculty of Health and Medical
Sciences, University of Copenhagen, Copenhagen, Denmark
OTTO GLATTER
Department of Chemistry, University of Graz, Graz, Austria
Abstract
The present contribution summarizes our previous investigations on the formation of
emulsions, whose particles consist of a self-assembled inverted-type liquid crystalline
phase or an inverted-type microemulsion. In this context, the main focus was on replac-
ing either the dispersed oil droplets in normal O/W emulsions, or the kinetically stabi-
lized internal W/O emulsion in double W/O/W emulsions, by an inverted-type liquid
crystalline phase or an inverted-type microemulsion system. Owing to the physico-
chemical properties of their internal nanostructures, these unique aqueous dispersions
are superior to conventional emulsions and double emulsions. They are attractive as
nanonreactors and as host systems for solubilizing active molecules (drugs, fl avors, and
vitamins) in the cosmetics, pharmaceutical, and food industries. This chapter describes
the effect of varying temperature and solubilizing oil on the reversible structural transi-
tions of the internal nanostructures of these lipidic dispersions.
5.1
Introduction
130
5.2
Emulsifi cation of MLO-Water Nanostructures
132
5.3
Emulsifi cation of Oil-Loaded Nanostructures
136
5.4
Stability of the Internally Oil - Loaded Nanostructures
139
5.5
The Breathing Mode
141
5.6
Modulation of the Internal Nanostructures
143
5.6.1
Oil - Free MLO - DGMO - and MLO - PC - Based Systems
143
5.6.2
Tuning Back the Curvature of Oil - Loaded MLO - Based
Aqueous Dispersions
147
5.7
Direct Liposomes - Cubosomes Transition
150
5.8
Food - Grade ISAsomes
151
5.9
Summary
151
References
152
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