Biology Reference
In-Depth Information
0 0 1
1 0 1
0 1 1
1 1 1
1 0 0
1 0 1
1 1 0
1 1 1
1 0 0
1 1 0
0 0 1
0 1 0
0 1 1
0 1 0
0 0 0
(C)
0 0 0
(A)
0 0 0
1 0 0
0 0 1
0 1 0
0 1 1
1 0 0
1 0 1
1 1 0
1 1 1
1 1 0
1 0 1
0 0 1
0 1 0
0 1 1
1 1 1
0 0 0
(B)
(D)
FIGURE 1.7
The state space transition diagram of triples (
M
,
E
,
L
) for the Boolean model of the
lac
operon defined in Eqs. (
1.4
) for the four possible combinations of parameter values. In
each of the cases, the operon has a single fixed point and no limit cycles. Panel (A)
L
e
=
0
;G
e
=
0; The operon is Off. Panel (B)
L
e
=
0
;G
e
=
1; The operon is Off. Panel (C)
L
e
=
1
;G
e
=
1; The operon is Off. Panel (D)
L
e
=
1
;G
e
= 0; The operon is On. Graphs
obtained using DVD [
12
].
1.3.5
Using Discrete Visualizer of Dynamics (DVD) to Test
a Boolean Model
The
Discrete Visualizer of Dynamics
(DVD) is a suite of freely available web applica-
tions (
http://dvd.vbi.vt.edu
)
that takes the transition functions of the Boolean model
Search WWH ::
Custom Search