Biodegradable Thermogelling Poly(Organophosphazenes) and Their Potential Biomedical Applications - In-Situ Gelling Polymers: For Biomedical Applications - page 56

Table 4 Functional biodegradable thermogelling poly(organophosphazenes)
Functional Group Cosubstituents T max (ºC) Category Functionality References

IleOEt/GlyGlyOH/AMPEG550 39,46 Polymer-drug conjugate Locally controlled delivery of cancer

therapeutics

[ 63 , 84 ]

GlyGlyDOX

GlyGlyGRGDS IleOEt/GlyGlyOH/AMPEG550 36.8-41.8 Polymer-drug conjugate Enhancement of mesenchymal stem

cell osteogenic differentiation

[ 65 ]

GlyGlyPTX IleOEt/GlyGlyOH/AMPEG500 35.8-39.8 Polymer-drug conjugate Controlled local release of antitumor

drug

[ 64 ]

IleOEt/GlyGlyOH/AMPEG500 49.8, 51.8 Polymer-drug complex Enhanced sustained human growth

hormone delivery

[ 67 ]

GlyGlyPro

IleOEt/AMPEG550/Succinic
acid

32.0,36.0 Polymer-drug complex Increased biological eficiency and

bioavailability of human growth hormone
and siRNA

[ 86 , 132 ]

PEI

Cysteamine IleOEt/AMPEG550 37.8-43.8 Chemically crosslinkable

hydrogel

Improvement of mechanical gel
strength and controlled inner network
and degradation rate

[ 134 , 135 ]

2-Aminoethyl
methacrylate

IleOEt/AMPEG550 23.9-57.9 Chemically crosslinkable

hydrogel

Tunable mechanical gel property and the
degradation rate

[ 135 - 137 ]

39.0

IleOEt/AMPEG750

IleOEt/GlyLacOEt/AMPEG550 37.0, 39.0

39.0, 41.0

IleOEt/GlyLacOEt/AMPEG750

IleOEt/AMPEG550 20.0-42.0 Chemically crosslinkable

hydrogel

Rapid photocrosslinking hydrogel with
enhanced mechanical strength

[ 138 ]

2-Aminoethyl
acrylate

[ 135 , 139 ]

Blending with cyseamine containing
polyphosphazene to form self-
crosslinkable hydrogel with improved
mechanical strength