Biomedical Engineering Reference
In-Depth Information
Table 3
Thermosensitive Poly(organophosphazenes)
Two cosubstituents
: Amino Acid/PEG [NP(NHCHR
1
COOR
3
)(R
2
)]
n
Hydrophobic substituent
(R
1
)
(R
3
)
Hydrophilic substituent (R
2
)
T
LCST
(ºC)
References
Glycine (GlyOEt)
H
Me
O(CH
2
CH
2
O)
7
CH
3
88.5
[
58
,
62
,
114
,
115
]
Bz
O(CH
2
CH
2
O)
7
CH
3
49.5
[
58
,
62
,
114
,
115
]
O(CH
2
CH
2
O)
7
CH
3
35.0-93.2
[
58
,
62
,
114
,
115
]
Et
98.5
[
62
,
114
,
115
]
O(CH
2
CH
2
O)
16
CH
3
62.0, >100
[
113
]
NH(CH
2
CH
2
O)
7
CH
3
CH
3
Et
O(CH
2
CH
2
O)
7
CH
3
67.0
[
58
,
62
]
Alanine
58.0, >100
[
113
]
NH(CH
2
CH
2
O)
7
CH
3
COOEt
Et
O(CH
2
CH
2
O)
7
CH
3
65.5
[
58
,
62
]
Aminomalonic acid
Aspartic acid
CH
2
COOEt
Me
O(CH
2
CH
2
O)
7
CH
3
84.3
[
62
]
Bz
O(CH
2
CH
2
O)
7
CH
3
33.8
[
62
]
O(CH
2
CH
2
O)
7
CH
3
38.5-60.2
[
58
,
62
,
114
]
Et
60.2-75
[
62
,
115
]
O(CH
2
CH
2
O)
16
CH
3
NH(CH
2
CH
2
O)
7
CH
3
38.5,61.5
[
113
]
(CH
2
)
2
COOEt
Et
O(CH
2
CH
2
O)
7
CH
3
25.2-66.5
[
62
]
Glutamic Acid
32.0,43.0
[
113
]
NH(CH
2
CH
2
O)
7
CH
3
NH(CH
2
CH
2
O)
16
CH
3
79.0
[
113
]
CH
3
Et
O(CH
2
CH
2
O)
7
CH
3
70.3
[
58
,
114
]
ʲ
-Alanine
65.0, >100
[
113
]
NH(CH
2
CH
2
O)
7
CH
3
Three cosubstituents
: Amino Acid/Amino Acid/PEG [NP(NHCHR
1
COOEt)(NHCHR
3
COOR
4
)(R
2
)]
n
Hydrophobic substituents
(R
1
)
(R
3
)
(R
4
)
Hydrophilic substituent (R
2
)
T
LCST
(ºC)
Reference
H
(CH
2
)
2
COOEt
Et
O(CH
2
CH
2
O)
7
CH
3
53.6
[
62
]
Glycine/Glutamic acid
Three cosubstituents
: Amino Acid/Depsipeptide/PEG [NP(NHCHR
1
COOEt)(NHCH
2
COOCHR
3
COOEt)(R
2
)]
n
Hydrophobic substituents
(R
1
)
(R
3
)
Hydrophilic substituent (R
2
)
T
LCST
(ºC)
References
Glycine/Ethyl-2-(
O
-glycyl)glycolate
H
H
O(CH
2
CH
2
O)
7
CH
3
64-70
[
60
]
H
CH
3
O(CH
2
CH
2
O)
7
CH
3
66
[
60
]
Glycine/Ethyl-2-(
O
-glycyl)lactate
Note
Me Methyl
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