Biomedical Engineering Reference
In-Depth Information
Table 1
Biodegradable Thermogelling Poly(organophosphazenes)
Two cosubstituents
: Amino Acid/PEG [NP(NHCHR
1
COOEt)(R
2
)]
n
Hydrophobic substituents
(R
1
)
Hydrophilic substituents (R
2
)
T
LCST
(ºC)
T
max
(ºC)
References
CH(CH
3
)CH
2
CH
3
NH(CH
2
CH
2
O)
7
CH
3
(AMPEG350)
37.0-74.0
29.0, 38.0
[
61
,
68
]
Isoleucine (IleuOEt)
75.0
31.0-61.0
[
55
-
57
,
61
,
66
,
71
-
74
]
NH(CH
2
CH
2
O)
11
CH
3
(AMPEG 550)
84.0
44.0-56.0
[
56
,
68
,
71
,
74
]
NH(CH
2
CH
2
O)
16
CH
3
(AMPEG 750)
Leucine (LeuOEt)
CH
2
CH(CH
3
)
2
NH(CH
2
CH
2
O)
7
CH
3
40.0
34.0
[
68
]
-
35.0, 40.0
[
71
,
75
]
NH(CH
2
CH
2
O)
11
CH
3
Valine
CH(CH
3
)
2
NH(CH
2
CH
2
O)
7
CH
3
54.0, 57.0
-
[
55
,
68
]
NH(CH
2
CH
2
O)
11
CH
3
-
51.0-54.0
[
56
,
71
,
75
]
Two cosubstituents
: Oligopeptide/PEG [NP(NHCHR
1
CONHCHR
3
CONHCHR
4
CONHCHR
5
COOEt)(O(CH
2
CH
2
O)
7
CH
3
)]
n
Hydrophobic substituent
(R
1
)
(R
3
)
(R
4
)
(R
5
)
T
LCST
(ºC)
T
max
(ºC)
References
H
CH
2
(C
5
H
6
)
CH
2
CH(CH
3
)
2
-
30.0
25.0
[
70
]
Glycyl-phenylalanyl-leucine (GlyPheLeuEt)
H
CH
2
(C
5
H
6
)
CH(CH
3
)CH
2
CH
3
-
39.0-50.0
28.0, 37.0
[
70
]
Glycyl-phenylalanyl-isoleucine (GlyPheIleuEt)
Glycyl-leucyl-phenylalanine (GlyLeuPheEt)
H
CH
2
CH(CH
3
)
2
CH
2
(C
5
H
6
)
-
35.0, 42.0
30.0, 32.0
[
70
]
H
CH
2
(C
5
H
6
)
CH
2
CH(CH
3
)
2
H
70.0
58.0
[
70
]
Glycyl-phenylalanyl-leucyl-glycine (GlyPheLeuGlyEt)
Three cosubstituents
: Amino Acid/Depsipeptide/PEG [NP(NHCHR
1
COOEt)(NHCH
2
COOCHR
3
COOEt)(R
2
)]
n
Hydrophobic substituents
(R
1
)
(R
3
)
Hydrophilic substituents (R
2
)
T
LCST
(ºC)
T
max
(ºC)
References
Isoleucine/
Ethyl-2-(
O
-glycyl)glycolate
CH(CH
3
)CH
2
CH
3
H
NH(CH
2
CH
2
O)
7
CH
3
54.0
39.0
[
68
]
75.0
48.0
[
68
]
NH(CH
2
CH
2
O)
11
CH
3
NH(CH
2
CH
2
O)
16
CH
3
51.0, 87.0
28.0, 62.0
[
68
]
CH(CH
3
)CH
2
CH
3
CH
3
NH(CH
2
CH
2
O)
7
CH
3
-
31.0-42.0
[
57
,
66
,
67
,
69
,
74
-
87
]
Isoleucine/
Ethyl-2-(
O
-glycyl)lactate (GlyLacOEt)
NH(CH
2
CH
2
O)
11
CH
3
-
41.0-57.0
[
74
,
86
]
(continued)
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