Introduction to In Situ Forming Hydrogels for Biomedical Applications - In-Situ Gelling Polymers: For Biomedical Applications - page 29

Compared with current microfracture treatment, the BST-CarGel system improved
the repair by successfully holding the cells/stem cells released from the microf-
ractured site. Both systems are already on the market. Another system is Regel ® ,
which was a pionieering system of biodegradable thermogelling system. The bio-
compatibility was good as evidenced by passing phase I clinical trial. However,
the paclitaxel loaded Regel ® (Oncogel) was stopped for further investigation
[ 132 ]. When a patient is diagnosed as a solid tumor, he/she immediately wants
surgery instead of waiting till the tumor size decreases by using the sustained
release of the anticancer drug from the in situ formed gel. Therefore, the treatment
was narrowed down for inoperable tumor such as inoperable esophageal cancer.
However, compared with current treatment of anticancer drug combined with radi-
otherapy, the additional treatment by using Oncogel did not significantly improve
the patient. Above cases studies suggest that the patient-oriented development of
an in situ gelling system is very important.
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