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(a)
120 ± 20 nm
Loading and photopolymerization
PEG-PE
PC/NH
2
-PEG-DSPE/
Cholesterol 3:1:1
Extrusion/freeze drying
Rehydration
UV washing
PLA
PEG
PLA
CD-Sb505 complex
IL-2
(b)
(c)
IL-2
Drug
No treatment
Soluble SB
Sol SB+IL-2
nLG-SB
nLG-IL-2
nLG-SB+IL-2
Time (days)
Time (days)
Fig. 14 a
nLGs were formulated from lyophilized liposomes loaded with biodegradable PLA-
PEG-PLA diacrylate, acrylated-CD-TGF-
ʲ
inhibitor complex, and IL-2 cytokine. After loading,
photopolymerization of the polymer and acrylated-CD induced gel formation.
b
Simultaneous
release of IL-2 and TGF-
ʲ
inhibitor released from co-loaded nLGs.
c
Tumor area growth versus
time. Reproduced from [
107
]
(silica shell crosslinked methoxy micelles; SSCMs) was developed as a potential
therapeutic contact lens material for long term treatment of ocular disease [
109
].
In vitro release of DMSA from SSCM embedded hydrogel system was observed
over a month. Multiple model drugs of low steric hindrance molecules (LSH) and
high steric hindrance molecules (HSH) loaded in the Agarose and Carbomer 974P
based hydrogel was suggested as a promising spinal cord injury repair system
[
110
]. LSH released almost completely in 1 day, whereas HSH released only 40 %
at day 1 and sustained released during 7 days in vitro. In vivo release was more
rapid than in vitro but release pattern was similar with in vitro. LSH can be drugs
for short-term neuroprotection purposes, while HSH can be drugs for long-term
neuroregeneration approaches. Anticancer drug of Paclitaxel (PTX) loaded PEG-
PCL-PEG (PECE) hydrogel showed steady release of PTX for up to 20 days in
vitro and prevented recurrence of breast cancer [
111
]. Another anticancer drug of
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