Biomedical Engineering Reference
In-Depth Information
Fig. 9
Different pathways to form a globular protein hydrogel; a tertiary structure as it gels into
a hydrogel with quaternary structure [
18
]
Fig. 10
Left
Rheology data showing the storage modulus of 0.5 wt% MAX8 (
I
) during initial
gelation, (
II
) as MAX8 undergoes steady-state shear, it becomes liquid like, (
III
) when shear
ceases, the gel immediately displays solid like behavior with G′ > 250 Pa and quickly recovers
original storage modulus.
Right
a
MAX1 after a single substitution difference for reduced overall
charge is known as
b
MAX8. The reduced charge leads to faster kinetics and gelation time for
MAX8, as evidenced by the effects of gravity on encapsulated MSCs [
73
]
more fibrillar entanglements overall in the quaternary structure. The consequently
stiffer hydrogels formed more quickly than more highly charged MAX1 networks
show affects on the distribution of encapsulated payloads. The faster gelation pre-
vents heavier items, such as cells, from sinking due to gravity before the fibril-
lar network finishes gelation, as seen in Fig.
10
[
73
]. The fibrillar network and
resultant molecular diffusion properties within the gel do not change significantly
between peptide gels because the method of fibrillar growth does not change [
51
].
One can also change the solution peptide folding and assembly triggering condi-
tions in order to change the amount of branching of the gel, which changes the
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