Biomedical Engineering Reference
In-Depth Information
Introduction to In Situ Forming Hydrogels
for Biomedical Applications
Bogyu Choi, Xian Jun Loh, Aloysius Tan, Chun Keat Loh, Enyi Ye,
Min Kyung Joo and Byeongmoon Jeong
Abstract
In situ gelling polymer aqueous solutions undergo sol-to-gel transition
through chemical and/or physical crosslinking. The criterion on sol and gel is an
important issue, therefore, rheology of hydrogel have been discussed in detail.
The in situ gelling system has been investigated for minimally invasive drug deliv-
ery, injectable tissue engineering, gene delivery, and wound healing. In this chap-
ter, in situ gelling systems and their various biomedical applications were briefly
summarized.
Keywords
Injectable
·
Rheology
·
Physical crosslinking
·
Thermogel
·
Tissue
engineering
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