Environmental Engineering Reference
In-Depth Information
All experimental microarray data can be accessed at http://funcgen.vectorbase.org/
ExpressionData/.
KEYWORDS
•
Aedes
aegypti
•
Aedes
detox
chip
•
Hemorrhagic fevers
•
Temephos
AUTHORS' CONTRIBUTIONS
Sébastien Marcombe participated in toxicological and biochemical studies together
with microarray screening and
kdr
genotyping and helped to draft the manuscript.
Rodolphe Poupardin participated in biochemical studies, microarray screening and
RT-qPCR. Frederic Darriet participated in toxicological studies. Stéphane Reynaud
participated in RT-qPCR and helped to draft the manuscript. Julien Bonnet partici-
pated in toxicological studies. Clare Strode participated in microarray study. Cecile
Brengues participated in
kdr
genotyping and sequencing. André Yébakima coordi-
nated field mosquito collection in Martinique and helped to draft the manuscript.
Hilary Ranson helped to draft the manuscript and coordinated the microarrays studies.
Vincent Corbel conceived of the study and participated in its design and coordination
and helped to draft the manuscript. Jean-Philippe David participated in the design of
the study and its coordination, performed microarray data analysis and conceived the
manuscript. All authors read and approved the final manuscript.
ACKNOWLEDGMENTS
The present research project was funded by the French Institut de Recherche pour
le Développement (IRD), the French Agency for Environmental Health and Safety
(grant AFSSET N° 13-12-2007 to Vincent Corbel) and the Laboratory of Alpine Ecol-
ogy of Grenoble (French National Research Agency grant ANR MOSQUITO-ENV
N° 07SEST014 to Jean-Philippe David and Stéphane Reynaud). We thank Manuel
Etienne and Said Crico for help on mosquito collection in Martinique. We thank Prof.
A. Cossins, Dr. M. Hughes and the Liverpool Microarray User Community for micro-
array printing. We thank Dr. B. MacCallum and Vectorbase community for valuable
help with microarray data deposition. We are grateful to Prof. P. Ravanel for useful
comments on the manuscript and J. Patouraux for technical help.
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