Biology Reference
In-Depth Information
Current
Future
Undiagnosed pancreatic
cyst
Preoperative patient
management
Molecular diagnosis of
IPMNs
Molecular diagnosis of
IPMN dysplasia grade
• Serous cystadenoma (SCA)
• Mucinous cystic neoplasm (MCN)
• Intraepithelial papillary mucinous
neoplasm (IPMN)
• Radiologic imaging
• EUS-FNA & cytology
• CEA level, DNA analysis
(mutations, LOH)
• Methodology: detect mutations in
KRAS codon 12 and GNAS codon
201
• Clinical application: confirm
differential diagnosis of IPMN vs.
SCA and MCN
• Methodology: measuring
expression levels of 9 miRNAs
• Clinical application: optimizing
treatment - surgery vs. observation
FIGURE 5.3
Current and proposed future clinical management of patients with pancreatic cystic lesions.
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