Chemistry Reference
In-Depth Information
4
Diastereoselective Pauson-Khand
Reaction using Chiral Pool
Techniques (Chiral Substrates)
Martin Kamlar, Jan Vesely, and Ramon Rios Torres
4.1 Introduction and Background
69
4.2 Intramolecular Diastereoselective Pauson-Khand Reaction
70
4.3 Intermolecular Diastereoselective Pauson-Khand Reaction
87
4.4 Conclusion
90
References
91
“Anyone who has never made a mistake has never tried anything new.”
—Albert Einstein
4.1
Introduction and Background
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The Pauson-Khand reaction is a formal [2
1] cycloaddition reaction that involves
an alkyne, an alkene, and carbon monoxide and is mediated by a hexacarbonyldicobalt
complex to yield cyclopentanones in a single step. Since its discovery, many asym-
metric Pauson-Khand reactions (PKRs) have been developed. In this chapter we will
2
