The Pauson-Khand Reaction –an Introduction - The Pauson-Khand Reaction - page 17

reaction has grown to become a synthetic method of immense value to the global chemistry
community. As discussed above, a series of methodological advances now allow this
annulation process to be used with preparative confidence, to deliver generally very good
levels of efficiency and selectivity in both an intra- and intermolecular sense. Accordingly
and as illustrated with some examples above, the PK technique is finding continual use in
targeted natural product synthesis (see Chapter 8). Furthermore and as will be detailed in
Chapters 4, 5, and 6, an array of enantioselective methods have also now been developed.
This monograph will describe the development and application of the Pauson-Khand
reaction and related processes over the 40-or-so years since the initial discovery of the
original cobalt-mediated annulations. The development of this method forms just one,
albeit significant, part of Peter Pauson's seminal contributions to organometallic methods
and organic synthesis. As for Dr Khand, one feels that he would be immensely pleased to
observe where his serendipitous discovery had been elevated to, as well as the impact that
this cyclisation process has had on preparative organic chemistry.

Acknowledgements

I am honoured and indebted to have had Peter Pauson as a mentor and friend for the past 28
years and I offer my sincerest gratitude for his unstinting guidance and support. I also thank
my own students and postdoctoral associates in the area of Pauson-Khand chemistry for their
dedication and inspiration: Steve Christie, Udo Lange, Gavin Forsyth, Tony Murray, Craig
Johnstone, Hans Donkervoort, George Kirk, Alison Gordon, Alastair Hay, Jamie Scott,
Gair Ford, John Caldwell, Sarah Robertson, Dave Lindsay, Elaine Rankin, Dave Carbery,
Mark McLaughlin, Angus Morrison, Iain Cameron, Paul Ratcliffe, Elaine Campbell, James
Crawford, Emma Carswell, Colin Pearson, Claire Russell, Graeme Thurston, Jack Brown,
Tomasz Janecki, Stephanie Irvine, Allan McPherson, Jacek K

edzia, Laura Paterson (nee
McEvoy), Alison Cochrane, Malcolm Gordon, and Calum Forsyth.

References

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Commun. , 36 (1971).
[2] (a) I. U. Khand, G. R. Knox, P. L. Pauson, W. E. Watts, and M. I. Foreman, J. Chem.
Soc., Perkin Trans. 1 , 977-981 (1973); (b) I. U. Khand, G. R. Knox, P. L. Pauson, and
W. E. Watts, J. Chem. Soc. , Perkin Trans. 1 , 975-977 (1973).
[3] P. L. Pauson and I. U. Khand, Ann. N. Y. Acad. Sci. , 295 , 2-14 (1977).
[4] Web of Science SM conducted on 26 September, 2011.
[5] (a) P. L. Pauson, Tetrahedron , 41 , 5855-5860 (1985); (b) P. L. Pauson, In
Organometallics in Organic Synthesis. Aspects of a Modern Interdisciplinary Field ,
A. de Meijere and H. tom Dieck (Eds), Springer, Berlin, 1988, pp 233-246;
(c) N. E. Schore, Org. React ., 40 , 1-90 (1991); (d) N. E. Schore, In Comprehensive
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pp 1037-1064; (e) O. Geis and H.-G. Schmalz, Angew. Chem. Int. Ed. , 37 , 911-914
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