Chemistry Reference
In-Depth Information
7
Recent Advancement of Catalytic
Pauson-Khand-type Reactions
Fuk Loi Lam, Hang Wai Lee, Jun Wang and Fuk Yee Kwong
∗
7.1 Introduction
181
7.2 Rhodium-Catalyzed Pauson-Khand-Type Cyclizations
182
7.3 Iridium-Catalyzed Pauson-Khand-Type Cyclizations
194
7.4 Titanium-Catalyzed Pauson-Khand-Type Cyclizations
198
7.5 Ruthenium-Catalyzed Pauson-Khand-Type Cyclizations
200
7.6 Nickel- and Palladium-Catalyzed Pauson-Khand-Type Cyclizations
201
7.7 Tandem Reactions and Miscellaneous (other than Co complex)
204
7.8 Conclusion
206
Acknowledgements
206
References
206
7.1
Introduction
Cycloaddition reaction is one of the most attractive synthetic protocols for accessing a
variety of scientifically interesting and pharmaceutically useful ring-structured skeletons.
This transformation is an addition reaction in which the waste materials (side products)
generated are expected to be minimized and thus is environmentally favourable. Indeed,
these significances have been highlighted by Trost: 'an ideal chemical reaction must be
not only selective, but also a simple addition in which the other reactants are required
only in catalytic amounts.'
1
In fact, transition-metal-mediated catalytic reactions can play
a versatile role in addressing the atom economy issue. One of the earliest examples is the
