Chemistry Reference
In-Depth Information
5
Asymmetric Intra- and Intermolecular
Pauson-Khand Reactions: The Chiral
Auxiliary Approach
Albert Moyano
5.1 Introduction
96
5.2 Asymmetric Intramolecular PKRs with the Aid of Chiral Auxiliaries
99
5.2.1 Chiral Alkoxyacetylenes
99
5.2.2 Chiral Acetylene Thioethers
104
5.2.3 Chiral 2-Alkynoate Derivatives
106
5.2.4 Chiral
O
-Alkyl Enol Ethers
108
5.2.5 Alkenyl Sulfoxides
113
5.2.6 Asymmetric Intramolecular PKRs Mediated by Chiral
Auxiliaries Located in the Enyne Tether
114
5.3 Asymmetric Intermolecular PKRs with the Aid of Chiral Auxiliaries
116
5.3.1 Chiral Alkoxyacetylenes
116
5.3.2 Chiral Acetylene Thioethers
124
5.3.3 Alkynyl Sulfoxides
125
5.3.4 Chiral Ynamines and Ynamides
126
5.3.5 Chiral 2-Alkynoates
128
5.3.6 Alkenyl Sulfoxides
135
5.4 Chiral Reagents for the Kinetic Resolution of PK Cycloadducts
138
5.5 Conclusion
140
Acknowledgements
140
References
140
