Protein structure - Pharmaceutical Biotechnology: Concepts and Aapplications - page 34

Table 2.9 Approved therapeutic proteins (listed by trade name) that are glycosylated. These products are
discussed in subsequent chapters. Reproduced from Walsh, G. and Jefferies, R. 2006. Nature Biotechnology
24 , 1241-1252

Product category Specifi c products (by trade name)

Blood factors, anticoagulants and thrombolytics Activase, Advate, Benefi x, Bioclate, Helixate/

Kogenate, Metalyse/TNKase, Novoseven,
Recombinate, Refacto, Xigiris

Antibodies Avastin, Bexxar, Erbitux, Herceptin, Humaspect,

Humira, Mabcampath/Campath-H1, Mabthera/
Rituxan, Mylotarg, Neutrospec, Oncoscint,
Orthoclone OKT-3, Prostascint, Raptiva, Remicade,
Simulect, Synagis, Xolair, Zenapax, Zevalin

Hormones Gonal F, Luveris, Ovitrelle/Ovidrel, Puregon/

Follistim, Thyrogen

EPO and colony-stimulating factors Epogen/Procrit, Leukine, Neorecormon, Nespo/Aranesp

Interferons Avonex, Rebif

Additional Aldurazyme, Amevive, Cerezyme, Enbrel,

Fabrazyme, Inductos, Infuse, Osigraft/OP-1
implant, Pulmozyme, Regranex, Replagal

O O

HN CH C

(a) HN CH C

CH 2
C

CH 2
C

O

Asp side-
chain

O

NH

NH 2

H 2 O

+

Sugar

OH

Sugar

O

O

(b)

HN CH C

HN CH C

CH 2
OH

CH 2
O

Serine
sidechain

Sugar

+

H 2 O

OH

Sugar

Figure 2.9 (a) N-linked versus (b) O-linked glycosylation. 'Sugar' represents an oligosaccharide chain, an
example of which is provided in Figure 2.10