Biomedical Engineering Reference
In-Depth Information
A number of such recombinant (subunit) vaccines have now been approved for general medi-
cal use (Table 13.9). The fi rst such product was that of hepatitis B surface antigen (rHBsAg),
which gained marketing approval from the FDA in 1986. Two billion people are infected with
hepatitis B worldwide, 350 million individuals suffer from life-long chronic infection, and more
Table 13.9
Recombinant subunit vaccines approved for human use
Product
Company
Indication
Recombivax (rHBsAg produced in
S. cerevisiae
)
Merck
Hepatitis B prevention
Comvax (combination vaccine, containing rHBsAg
produced in
S. cerevisiae
, as one component)
Merck
Vaccination of infants against
H. infl uenzae
type b and hepatitis B
Engerix B (rHBsAg produced in
S. cerevisiae
)
Smithkline Beecham
Vaccination against hepatitis B
Tritanrix-HB (combination vaccine, containing
rHBsAg produced in
S. cerevisiae
as one
component)
Smithkline Beecham
Vaccination against hepatitis B,
diphtheria, tetanus and pertussis
Lymerix (rOspA, a lipoprotein found on the surface
of
Borrelia burgdorferi
, the major causative
agent of Lyme's disease. Produced in
E. coli
)
Smithkline Beecham
Lyme disease vaccine
Infanrix-Hep B (combination vaccine,
containing rHBsAg produced in
S. cerevisia
e as one component)
Smithkline Beecham
Immunization against diphtheria,
tetanus, pertussis and hepatitis B
Infanrix-Hexa (combination vaccine, containing
rHBsAg produced in S. cerevisiae as one
component)
Smithkline Beecham
Immunization against diphtheria,
tetanus, pertussis, polio,
H.
infl uenzae
b and hepatitis B
Infanrix-Penta (combination vaccine,
containing rHBsAg produced in
S. cerevisiae
as one component)
Smithkline Beecham
Immunization against diphtheria,
tetanus, pertussis, polio, and
hepatitis B
Ambirix (combination vaccine, containing rHBsAg
produced in
S. cerevisiae
as one component)
Glaxo SmithKline
Immunization against hepatitis A
and B
Twinrix, adult and pediatric forms in EU
(combination vaccine containing rHBsAg
produced in
S. cerevisiae
as one component)
Smithkline Beecham
(EU)
Glaxo Smithkline
(USA)
Immunization against hepatitis A
and B
Primavax (combination vaccine, containing
rHBsAg produced in
S. cerevisiae
as one
component)
Pasteur Merieux
MSD
Immunization against diphtheria,
tetanus and hepatitis B
Procomvax (combination vaccine, containing
rHBsAg as one component)
Pasteur Merieux
MSD
Immunization against
H. infl uenzae
type b and hepatitis B
Hexavac (combination vaccine, containing
rHBsAg produced in
S. cerevisiae
as one
component)
Aventis Pasteur
Immunization against diphtheria,
tetanus, pertussis, hepatitis B,
polio and
H. infl uenzae
type b
Triacelluvax (combination vaccine containing
r(modifi ed) pertussis toxin
Chiron SpA
Immunization against diphtheria,
tetanus and pertussis
Hepacare (r S, pre-S and pre-S2 hepatitis B
surface antigens, produced in a mammalian
(murine) cell line)
Medeva Pharma
Immunization against hepatitis B
HBVAXPRO (rHBsAg produced in
S. cerevisiae
)
Aventis Pharma
Immunization of children &
adolescents against hepatitis B
Dukoral (combination vaccine containing
rCholera toxin B subunit as one component
SBL Vaccin AB
Active immunization against diseases
caused by
Vibrio cholerae
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