Biomedical Engineering Reference
In-Depth Information
Table 13.2
(
Continued
)
Product
Company
Indication
LeukoScan (Sulesomab, murine Mab fragment
(Fab) directed against NCA 90, a surface
granulocyte non-specifi c cross-reacting
antigen)
Immunomedics
Diagnostic imaging for infection/
infl ammation in bone of patients
with osteomyelitis
Humaspect (Votumumab, human Mab directed
against cytokeratin tumour-associated
antigen)
Organon Teknika
Detection of carcinoma of the colon
or rectum
Mabthera (Rituximab, chimaeric Mab directed
against CD 20 surface antigen of B-
lymphocytes)
Hoffmann La Roche
(see also Rituxan)
Non-Hodgkin's lymphoma
Mabcampath (EU) or Campath (USA);
alemtuzumab; a humanized monoclonal
antibody directed against CD52 surface
antigen of B-lymphocytes)
Millennium & ILEX
(EU); Berlex,
ILEX Oncology
& Millennium
Pharmaceuticals
(USA)
Chronic lymphocytic leukaemia
Mylotarg (Gemtuzumab zogamicin; a
humanized antibody-toxic antibiotic
conjugate targeted against CD33 antigen
found on leukaemic blast cells)
Wyeth Ayerst
Acute myeloid leukaemia
Zevalin (Ibritumomab Tiuxetan; murine
monoclonal antibody, produced in a
CHO cell line, targeted against the CD20
antigen)
IDEC Pharmaceuticals
Non-Hodgkin's lymphoma
Humira (EU & USA; also sold as Trudexa
in EU) (adalimumab; r (anti-TNF) human
monoclonal antibody created using phage
display technology
Cambridge Antibody
Technologies &
Abbott (USA)
Abbott (EU)
Rheumatoid arthritis
Bexxar (tositumomab; murine monoclonal
raised against CD 20 surface antigen, found
on the surface of B-lymphocytes)
Corixa and
GlaxoSmithKline
Non-Hodgkin's lymphoma
Erbitux (cetuximab; chimaeric antibody raised
against human EGF receptor)
ImClone Systems
and Bristol-Myers-
Squibb (USA)
Merck (EU)
Treatment of EGF receptor-
expressing metastatic colorectal
cancer
Xolair (omalizumab; humanized monoclonal
which binds immunoglobulin E at the site of
high affi nity IgE receptor binding)
Genentech/Novartis/
Ta nox / Sa n k yo
Treatment of adults/adolescents
with moderate to severe persistent
asthma
Raptiva (efalizumab; humanized antibody
expressed in CHO cell line. Binds to the
LFA-1, which is expressed on all leukocytes)
Genentech (USA)
Serono (EU)
Treatment of adult patients with
chronic moderate to severe plaque
psoriasis
Avastin (humanized monoclonal raised against
vascular endothelial growth factor).
Genentech USA)
Roche (EU)
Carcinoma of the colon or rectum
Tysabri (humanized monoclonal raised against
selected leukocyte integrins)
Biogen Idec/Elan
Treatment of patients with relapsing
forms of MS
NeutroSpec (murine monoclonal antibody
raised against CD15 surface antigen of
selected leukocytes)
Palatin Technologies/
Mallinckrodt Inc.
Imaging of equivocal appendicitis
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