Biomedical Engineering Reference
In-Depth Information
Table 13.2
Monoclonal/engineered antibodies thus far approved for medical use. The sponsoring
companies and therapeutic indications are also listed
Product
Company
Indication
CEA-Scan (Arcitumomab, murine Mab
fragment (Fab), directed against human
CEA)
Immunomedics
Detection of recurrent/metastatic
colorectal cancer
MyoScint (Imiciromab-Pentetate, murine Mab
fragment directed against human cardiac
myosin)
Centocor
Myocardial infarction imaging agent
OncoScint CR/OV (Satumomab Pendetide,
murine Mab directed against TAG-72, a
high molecular weight tumour associated
glycoprotein)
Cytogen
Detection/staging/follow up of
colorectal and ovarian cancers
Orthoclone OKT3 (Muromomab CD3, murine
Mab directed against the T-lymphocyte
surface antigen CD3)
Ortho Biotech
Reversal of acute kidney transplant
rejection
ProstaScint (Capromab Pentetate murine Mab
directed against the tumour surface antigen
PSMA)
Cytogen
Detection/staging/follow up of
prostate adenocarcinoma
ReoPro (Abciximab, Fab fragments derived
from a chimaeric Mab, directed against the
platelet surface receptor GPII
b
/III
a
)
Centocor
Prevention of blood clots
Rituxan (Rituximab chimaeric Mab directed
against CD20 antigen found on the surface
of B-lymphocytes)
Genentech/IDEC
Pharmaceuticals
Non-Hodgkin's lymphoma
Verluma (Nofetumomab murine Mab
fragments (Fab) directed against carcinoma-
associated antigen)
Boehringer Ingelheim/
NeoRx
Detection of small cell lung cancer
Zenapax (Daclizumab, humanized Mab
directed against the α chain of the IL-2
receptor)
Hoffman La Roche
Prevention of acute kidney transplant
rejection
Simulect (Basiliximab, chimaeric Mab
directed against the α chain of the IL-2
receptor)
Novartis
Prophylaxis of acute organ rejection
in allogeneic renal transplantation
Remicade (Infl iximab, chimaeric Mab directed
against TNF-α)
Centocor
Treatment of Crohn's disease
Synagis (Palivizumab, humanized Mab
directed against an epitope on the surface of
respiratory syncytial virus)
MedImmune (USA)
Abbott (EU)
Prophylaxis of lower respiratory
tract disease caused by respiratory
syncytial virus in paediatric
patients
Herceptin (Trastuzumab, humanized antibody
directed against HER2, i.e. human
epidermal growth factor receptor 2)
Genentech (USA)
Roche Registration
(EU)
Treatment of metastatic breast
cancer if tumour overexpresses
HER2 protein
Indimacis 125 (Igovomab, Murine Mab
fragment (Fab
2
) directed against the tumour-
associated antigen CA 125)
CIS Bio
Diagnosis of ovarian
adenocarcinoma
Tecnemab KI (murine Mab fragments (Fab/
Fab
2
mix) directed against HMW-MAA, i.e.
high molecular weight melanoma-associated
antigen)
Sorin
Diagnosis of cutaneous melanoma
lesions
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