Biomedical Engineering Reference
In-Depth Information
Extrinsic
pathway
Intrinsic
pathway
Xa
Thrombin
(IIa)
Prothrombin
(II)
Fibrin
(Ia)
Fibrinogen
(I)
Aggregation
XIIIa
Covalent
crosslinking
Hard
clot
Soft
clot
Figure 12.3
Overview of the blood coagulation cascade, with emphasis upon the molecular detail of its
terminal stages. Refer to text for specifi c detail
Injured blood
vessel
Red blood
cell
Vasoconstriction
of vessel
Aggregated,
cross-linked
fibrin
Platelet
Figure 12.4
Terminal steps of a blood clot (haemostatic plug): cross-linked fi brin molecules bind together
platelets and red blood cells congregated at the site of damage, thus preventing loss of any more blood
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