Growth factors - Pharmaceutical Biotechnology: Concepts and Aapplications

Biomedical Engineering Reference

In-Depth Information

Table 10.1 Overview of some polypeptide growth factors. Many can be grouped into families on the basis

of amino acid sequence homology, or the cell types affected. Most growth factors are produced by more

than one cell type and display endocrine, paracrine or autocrine effects on target cells by interacting with

specifi c cell surface receptors

Growth factor

Major target cells

Interleukins

Various, mainly cells mediating immunity and infl ammation

IFN-γ

Mainly lymphocytes and additional cells mediating immunity

(and infl ammation)

CSFs

Mainly haemopoietic cells

EPO

Erythroid precursor cells

TPO

Mainly megakaryocytes

Neurotrophic factors

Several, but mainly neuronal cell populations

Insulin

Various

IGFs

A very wide range of cells found in various tissue types

EGF

Various, including epithelial and endothelial cells and fi broblasts

PDGF

Various, including fi broblasts, glial cells and smooth muscle cells

FGFs

Various, including fi broblasts, osteoblasts and vascular endothelial cells

TGFs-α

Va r ious

LIF

Mainly various haemopoietic cells

Table 10.2 Growth factors approved for general medical use

Product a

Indication

Company

Neupogen (fi lgrastim; G-CSF)

Neutropenia caused by chemotherapy

Bone marrow transplants

Amgen Inc.

Leukine (sargramostim, GM-CSF)

Autologous bone marrow

transplantation Neutrophil recovery

after bone marrow transplantation

Berlex Labs

Neulasta (PEGylated fi lgrastim, see

above)

Neutropenia

Amgen

Epogen (epoetin alfa, rEPO)