Biomedical Engineering Reference
In-Depth Information
Figure 8.4
Outline of how the 2
-5
synthetase system promotes its antiviral effect. The 2
-5
phosphodi-
esterase 'off switch' is omitted for clarity. Refer to text for details
component of this system. It functions as an off switch, as it rapidly degrades the 2
-5
A
n
oligo-
nucleotides. Although this enzyme also appears to be expressed constitutively, interferon binding
appears to increase its expression levels in most cells.
8.2.9 TheeIF-2
α
protein kinase system
Intracellular replication of viral particles depends entirely upon successful intracellular transcrip-
tion of viral genes with subsequent translation of the viral mRNA. Translation of viral or cellular
mRNA is dependent upon ribosome formation. Normally, several constituent molecules interact
with each other on the mRNA transcript, forming the smaller ribosomal subunit. Subsequent for-
mation/attachment of the larger subunit facilitates protein synthesis.
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