Biomedical Engineering Reference
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(a)
C
C
C
CH
2
CH
2
CH
2
[O]
[O]
CH
2
CH
2
CH
2
O
O
O
S
S
S
CH
3
CH
3
CH
3
Sulphoxide
Sulphone
Methionine
side chain
(b)
C
C
C
C
[O]
+
CH
2
CH
2
CH
2
CH
2
SH
SH
S
S
Cysteine residues
Disulphide bond
formation
[O]
C
CH
2
SO
3
H
Cysteic acid
(sulphonic acid)
Figure 6.20
Oxidation of (a) methionine and (b) cysteine side chains, as can occur upon exposure to air or
more potent oxidizing agents (e.g. peroxide, superoxide, hydroxyl radicals or hypochlorite). Refer to text for
specifi c details
(a)
S
S
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
S
S
S
S
S
S
(b)
O
O
O
O
O
O
O
O
OOOOOOOO
S
S
S
S
+
S
S
OOOOOOO O
S
OOOOOOOO
S
Figure 6.21
Diagram representing the molecular process of intrachain (a) and interchain (b) disulfi de ex-
change. Refer to text for specifi c details. (—O— are amino acid residues in the polypeptide)
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