Biomedical Engineering Reference
In-Depth Information
Figure 5.8
(
Continued
)
5.3.2 Microbial cell fermentation
Over half of all biopharmaceuticals thus far approved are produced in recombinant
E. coli
or
S. cerevisiae
. Industrial-scale bacterial and yeast fermentation systems share many common
features, an overview of which is provided below. Most remaining biopharmaceuticals are pro-
duced using animal cell culture, mainly by recombinant BHK or CHO cells (or hybridoma cells in
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