Biomedical Engineering Reference
In-Depth Information
signals from the culture substrate. By carefully controlling these mechanophysical
factors, MSC fate decision toward adipogenesis can be controlled (ideally, pro-
hibited) for preventing obesity. Further, soluble and mechanophysical cues can
work together to elevate the sensitivity of MSCs to respond to mechanical signals
in downregulating the adipogenesis. Even substrate cue and mechanical cell
stimuli may have synergistic effects in controlling MSC adipogenesis. As more
and more information is gathered regarding the inhibition of MSC adipogenesis,
we will be able to find better approaches to deal with obesity and related metabolic
diseases. In addition, finding conditions to increase MSC osteogenesis (potentially
at the expense of reduced adipogenesis) will help to develop advanced bone tissue
engineering protocols.
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