Mechanical Stretching and Signaling Pathways in Adipogenesis - The Mechanobiology of Obesity and Related Diseases - page 48

Table 1 Effects of mechanical stimuli on adipogenesis
Conditions

Cell Mechanotransduciton Effect on

adipogenesis
(or cell fate)

Refs

Axis Motion Strength Duration Name Character Signal Downstream

Uni-axial Cyclic 130% 2 days 3T3-L1 preadipocyte p-ERK : PPARc 2 ; Inhibition [ 14 , 15 ]

1 Hz (mouse) COX-2 :

110% 14 days ASC MSC uncertain uncertain (osteogenic) [ 28 ]

1 Hz (4 h/day) (human)

110% 1 or 3 days MSC MSC uncertain uncertain (myogenic) [ 31 ]

1 Hz (rat)

2000 le 6 h ASC MSC p-ERK: PPARc ; Inhibition [ 34 ]

1 Hz (rat)

105% 2—4 h Embryonic lung MSC TIP-1 : PPARc 2 ; Inhibition [ 133 ]

0.5 Hz (mouse) TIP-3 ; SRF :

Multi-/ Cyclic 120% 3 days C2C12 MSC WntlOB : PPARc ; Inhibition [ 26 ]

equibi-axial 0.1 Hz (mouse)

4000 le 14 days C3H10T1/2 MSC uncertain PPARc 2 ; Inhibition [ 27 ]

1 Hz (300 cycles/days) (mouse)

4000 le 14 days MSC MSC uncertain PPARc 2 ; Inhibition [ 27 ]

1 Hz (300 cycles/days) (bovine) Runx2 :

110% 3 or 5 days C3H10T1/2 MSC p-ERK: PPARc; Inhibition [ 29 ]

0.01 Hz (mouse)

110% 4 days C3H10T1/2 MSC p-ERK: PPARc; Inhibition [ 30 ]

0.25 Hz (2 h/day) (mouse) C/EBPa ;

110% 3 or 5 days C3H10T1/2 MSC ß-catenin : PPARc ; Inhibition [ 32 ]

0.167 Hz (6 h/day) (mouse) Runx2 : (osteogenic)

110% 10min or 24 h HUCPVC MSC TGFßl PPARc ; Inhibition [ 33 ]

0.5 Hz or 60 h (human) —p-Smad2 : C/EBPa ; (osteogenic)

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