Mechanotransduction and the Myogenic Response in Diabetes - The Mechanobiology of Obesity and Related Diseases - page 229

Fig. 1 Schematic diagram outlining signaling events involved in myogenic vasoconstriction.
The pathway is considered as being comprised of 4 elements based on functional properties—a
mechanosensory step followed by transduction of the mechanical stimulus to the contractile
proteins. Activation of the contractile proteins leads to vessel contraction that, in the intact
system, would be expected to prevent or decrease the transmission of the initial increase pressure
downstream to smaller blood vessels

muscle cell stretch or an increase in wall tension. At a simplistic level these events
lead to membrane depolarization, opening of plasma membrane voltage-gated
Ca 2+ channels (VGCCs) and activation of the contractile proteins.