Extracellular Matrix Remodeling and Mechanical Stresses as Modulators of Adipose Tissue Metabolism and Inflammation - The Mechanobiology of Obesity and Related Diseases - page 118

mesenchymal stem cells. J. Orthop. Res. (official publication of the Orthopaedic Research
Society) 28(11), 1531-1538 (2010). doi: 10.1002/jor.21156
54. Sen, B., Styner, M., Xie, Z., Case, N., Rubin, C.T., Rubin, J.: Mechanical loading regulates
NFATc1 and beta-catenin signaling through a GSK3beta control node. J. Biol. Chem.
284(50), 34607-34617 (2009). doi: 10.1074/jbc.M109.039453
55. Sen, B., Xie, Z., Case, N., Styner, M., Rubin, C.T., Rubin, J.: Mechanical signal influence on
mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the
loading regimen. J. Biomech. 44(4), 593-599 (2011). doi: 10.1016/j.jbiomech.2010.11.022
56. Huang, S.C., Wu, T.C., Yu, H.C., Chen, M.R., Liu, C.M., Chiang, W.S., Lin, K.M.:
Mechanical strain modulates age-related changes in the proliferation and differentiation of
mouse adipose-derived stromal cells. BMC Cell Biol. 11, 18 (2010). doi: 10.1186/

1471-2121-11-18
57. Shoham, N., Gottlieb, R., Sharabani-Yosef, O., Zaretsky, U., Benayahu, D., Gefen, A.: Static
mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the
MEK signaling pathway. Am. J. Physiol. Cell Physiol. 302(2), C429-C441 (2012). doi: 10.
1152/ajpcell.0 . 0167.2011
58. Levy, A., Enzer, S., Shoham, N., Zaretsky, U., Gefen, A.: Large, but not small sustained
tensile strains stimulate adipogenesis in culture. Ann. Biomed. Eng. 40(5), 1052-1060
(2012). doi: 10.1007/s10439-011-0496-x
59. Hossain, M.G., Iwata, T., Mizusawa, N., Shima, S.W., Okutsu, T., Ishimoto, K., Yoshimoto,
K.: Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of
PPARgamma2 and C/EBPalpha. J. Biosci. Bioeng. 109(3), 297-303 (2010). doi: 10.1016/j.
jbiosc.2009.09.003
60. Tchoukalova, Y.D., Koutsari, C., Karpyak, M.V., Votruba, S.B., Wendland, E., Jensen, M.D.:
Subcutaneous adipocyte size and body fat distribution. Am. J. Clin. Nutr. 87(1), 56-63 (2008)
61. Hirsch, J., Batchelor, B.: Adipose tissue cellularity in human obesity. Clin. Endocrinol.
Metab. 5(2), 299-311 (1976)
62. Schiele, N.R., Marturano, J.E., Kuo, C.K.: Mechanical factors in embryonic tendon
development: potential cues for stem cell tenogenesis. Curr. Opin. Biotechnol. 24(5),
834-840 (2013). doi: 10.1016/j.copbio.2013.07.003